Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.31 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 4/20 | 0.31 |
| ▸ | PKM | P14618 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | CASP1 | P29466 | 2/20 | 0.31 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 2/20 | 0.31 |
| ▸ | BLM | P54132 | 2/20 | 0.31 |
| ▸ | CASP7 | P55210 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7063673 | 0.79 | KDM4E (0.35) | KDM4EALDH1A1NPC1RAB9ATP53 | |
| Hydrochloric Acid SCHEMBL7734531 | 0.79 | KDM4E (0.32) | KDM4EALDH1A1NPC1RAB9ATP53 | |
| Hydrochloric Acid SCHEMBL6289886 | 0.76 | CHRNB2 (0.32) | — | |
| Hydrochloric Acid SCHEMBL6285341 | 0.62 | — | — | |
| SCHEMBL40599 | 0.61 | GPR3 (0.52) | POLBMEN1KMT2A | |
| SCHEMBL29641604 | 0.61 | GPR3 (0.52) | POLBMEN1KMT2A | |
| SCHEMBL2459563 | 0.59 | KDM4E (0.43) | KDM4EALDH1A1NPC1RAB9ATP53 | |
| SCHEMBL13091138 | 0.59 | NPC1 (0.43) | KDM4EALDH1A1NPC1RAB9ATP53 | |
| SCHEMBL15556161 | 0.58 | TSHR (0.36) | KDM4EALDH1A1NPC1RAB9ATP53 | |
| SCHEMBL28814695 | 0.58 | GPR3 (0.36) | POLBMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479646-B1 | Metallocene compounds having indenyl ligand and catalysts for olefin polymerization containing the same | CHISSO CORPORATION (JP) | 2002-11-12 | — | — | US | disclosed |