Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7729620 | 1.00 | HSD11B1 (0.53) | HSD11B1SIGMAR1DRD4KMT2ARAB9A | |
| SCHEMBL7719776 | 0.97 | HSD11B1 (0.52) | HSD11B1SIGMAR1DRD4KMT2ARAB9A | |
| SCHEMBL7719781 | 0.97 | HSD11B1 (0.52) | HSD11B1SIGMAR1DRD4KMT2ARAB9A | |
| SCHEMBL7719871 | 0.94 | HSD11B1 (0.59) | HSD11B1SIGMAR1DRD4KMT2ARAB9A | |
| SCHEMBL7729574 | 0.94 | HSD11B1 (0.59) | HSD11B1SIGMAR1DRD4KMT2ARAB9A | |
| SCHEMBL7719868 | 0.94 | HSD11B1 (0.59) | HSD11B1SIGMAR1DRD4KMT2ARAB9A | |
| SCHEMBL7724369 | 0.90 | KMT2A (0.48) | DRD4KMT2ARAB9AEPHX1KDM1A | |
| SCHEMBL7724059 | 0.90 | DRD2 (0.50) | DRD4KMT2ARAB9AEPHX1CXCR3 | |
| SCHEMBL7724365 | 0.90 | KMT2A (0.48) | DRD4KMT2ARAB9AEPHX1KDM1A | |
| SCHEMBL7724063 | 0.90 | DRD2 (0.50) | DRD4KMT2ARAB9AEPHX1CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6468998-B1 | ANTAGONIZE SEROTONIN 2 RECEPTORS, SUPPRESS PLATELET AGGREGATION, IMPROVE PERIPHERAL CIRCULATION AND PROMOTE LACHRYMATION | MITSUBISHI PHARMA CORPORATION (JP) | 2002-10-22 | — | — | US | claimed |
| EP-1125922-A1 | PYRROLIDINE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF | Welfide Corporation (JP) | 2001-08-22 | — | — | EP | claimed |
| US-6468998-B1 | ANTAGONIZE SEROTONIN 2 RECEPTORS, SUPPRESS PLATELET AGGREGATION, IMPROVE PERIPHERAL CIRCULATION AND PROMOTE LACHRYMATION | MITSUBISHI PHARMA CORPORATION (JP) | 2002-10-22 | — | — | US | disclosed |
| EP-1125922-A1 | PYRROLIDINE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF | Welfide Corporation (JP) | 2001-08-22 | — | — | EP | disclosed |