Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 5/20 | 0.77 |
| ▸ | NOS2 | P35228 | 5/20 | 0.77 |
| ▸ | NOS3 | P29474 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7049127 | 0.91 | NOS1 (0.82) | NOS1NOS2NOS3 | |
| SCHEMBL7737987 | 0.91 | NOS1 (0.76) | NOS1NOS2NOS3 | |
| SCHEMBL2834765 | 0.90 | NOS1 (0.65) | NOS1NOS2NOS3 | |
| SCHEMBL7737402 | 0.90 | NOS1 (0.73) | NOS1NOS2NOS3 | |
| SCHEMBL7736686 | 0.87 | NOS1 (1.00) | NOS1NOS2NOS3 | |
| SCHEMBL7737313 | 0.85 | NOS1 (0.72) | NOS1NOS2NOS3 | |
| SCHEMBL7737467 | 0.85 | NOS2 (0.73) | NOS1NOS2NOS3 | |
| SCHEMBL19405312 | 0.84 | NOS1 (0.88) | NOS1NOS2NOS3 | |
| SCHEMBL14701552 | 0.84 | NOS1 (0.71) | NOS1NOS2NOS3 | |
| SCHEMBL7737413 | 0.84 | NOS1 (1.00) | NOS1NOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8932842-B2 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2015-01-13 | — | — | US | disclosed |
| US-8932842-B2 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2015-01-13 | — | — | US | disclosed |
| US-20130040359-A1 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2013-02-14 | — | — | US | disclosed |
| US-20130040359-A1 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2013-02-14 | — | — | US | disclosed |
| US-8278084-B2 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2012-10-02 | — | — | US | disclosed |
| US-8278084-B2 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2012-10-02 | — | — | US | disclosed |
| WO-2010093787-A2 | AMINOPYRIDINE DIMER COMPOUNDS, COMPOSITIONS AND RELATED METHODS FOR NEURONAL NITRIC OXIDE SYNTHASE INHIBITION | NORTHWESTERN UNIVERSITY (US) | 2010-08-19 | — | — | WO | disclosed |
| US-20100203613-A1 | Aminopyridine Dimer Compounds, Compositions and Related Methods for Neuronal Nitric Oxide Synthase Inhibition | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-08-12 | — | — | US | disclosed |
| US-20100203613-A1 | Aminopyridine Dimer Compounds, Compositions and Related Methods for Neuronal Nitric Oxide Synthase Inhibition | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040359-A1 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NOS2, NOS1, NOS3 | NOS1 2/4885NOS2 1/4885NOS3 3/4885 |
| US-20100203613-A1 | Aminopyridine Dimer Compounds, Compositions and Related Methods for Neuronal Nitric Oxide Synthase Inhibition | NOS2, NOS1, NOS3 | NOS1 2/4885NOS2 1/4885NOS3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.