SCHEMBL7730636

SCHEMBL7730636

CCCc1ccc(C(F)(F)Oc2ccc(-c3cc(F)c(OC(F)(F)F)c(F)c3)cc2)cc1

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.35
PRMT6 Q96LA8 1/20 0.34
CHRNA7 P36544 1/20 0.34
SERPINE1 P05121 2/20 0.34
PPARD Q03181 2/20 0.34
PPARA Q07869 2/20 0.34
PPARG P37231 1/20 0.34
FFAR4 Q5NUL3 1/20 0.34
CNR1 P21554 1/20 0.34
RARB P10826 2/20 0.33
TSHR P16473 1/20 0.33
RARA P10276 1/20 0.33
RARG P13631 1/20 0.33
DAO P14920 1/20 0.33
SLC6A4 P31645 2/20 0.33
SLC6A3 Q01959 2/20 0.33
ERBB2 P04626 1/20 0.33
ERBB4 Q15303 1/20 0.33
GRM2 Q14416 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7731928 0.93 RARB (0.39) MAOBPRMT6SERPINE1PPARAPPARG
SCHEMBL7733508 0.92 RARB (0.44) PPARAPPARGRARBTSHRRARA
SCHEMBL7731615 0.91 TSHR (0.35) MAOBTSHRDAOSLC6A4SLC6A3
SCHEMBL7722612 0.90 PRMT6 (0.38) PRMT6CHRNA7SERPINE1PPARDPPARA
SCHEMBL7733390 0.90 DAO (0.37) MAOBPPARDPPARAFFAR4TSHR
SCHEMBL17365910 0.90 GRM2 (0.34) CHRNA7FFAR4RARBTSHRDAO
SCHEMBL7729622 0.89 MAOB (0.37) MAOBPPARDPPARAPPARGRARB
SCHEMBL14226547 0.89 MAOB (0.37) MAOBPPARDPPARAPPARGRARB
SCHEMBL7734998 0.89 TAAR1 (0.33) MAOBTSHRDAOSLC6A4SLC6A3
SCHEMBL7731652 0.88 MAOB (0.39) MAOBPPARDPPARAPPARGRARB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed
EP-0786445-A1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORPORATION (JP) 1997-07-30 EP disclosed