Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CETP | P11597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8149676 | 1.00 | NFKB1 (0.34) | NFKB1NFKB2RELANR1H2HSD11B1 | |
| SCHEMBL7721935 | 0.83 | NR1H2 (0.39) | NFKB1NFKB2RELANR1H2HSD11B1 | |
| SCHEMBL7728185 | 0.83 | HSD17B10 (0.34) | NFKB1NFKB2RELANR1H2HSD11B1 | |
| SCHEMBL8150172 | 0.83 | NR1H2 (0.39) | NFKB1NFKB2RELANR1H2HSD11B1 | |
| SCHEMBL7727961 | 0.83 | HSD17B10 (0.34) | NFKB1NFKB2RELANR1H2HSD11B1 | |
| SCHEMBL7722122 | 0.83 | NR1H2 (0.39) | NFKB1NFKB2RELANR1H2HSD11B1 | |
| SCHEMBL7726101 | 0.83 | HSD17B10 (0.34) | NFKB1NFKB2RELANR1H2HSD11B1 | |
| SCHEMBL7726393 | 0.82 | PTPN1 (0.39) | NFKB1NFKB2RELANR1H2HSD11B1 | |
| SCHEMBL7733813 | 0.82 | PTPN1 (0.39) | NFKB1NFKB2RELANR1H2HSD11B1 | |
| SCHEMBL7733526 | 0.82 | PTPN1 (0.39) | NFKB1NFKB2RELANR1H2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |