SCHEMBL7732213

SCHEMBL7732213

CCCc1ccc(C(F)(F)Oc2ccc(CCc3cc(F)c(C(F)(F)F)c(F)c3)cc2)cc1

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
DAO P14920 2/20 0.36
MAOB P27338 3/20 0.35
THRB P10828 1/20 0.35
TAAR1 Q96RJ0 1/20 0.34
GPR84 Q9NQS5 1/20 0.34
PSMB5 P28074 1/20 0.33
SENP8 Q96LD8 1/20 0.33
SENP7 Q9BQF6 1/20 0.33
SENP6 Q9GZR1 1/20 0.33
PPARA Q07869 4/20 0.32
PPARD Q03181 3/20 0.32
PPARG P37231 2/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7735261 0.93 MAOB (0.36) DAOMAOBTHRBTAAR1GPR84
SCHEMBL7734945 0.92 PSEN1 (0.36) DAOMAOBTHRBTAAR1GPR84
SCHEMBL7722827 0.92 DAO (0.36) DAOMAOBTAAR1GPR84PPARA
SCHEMBL7730459 0.92 DAO (0.38) DAOMAOBTHRBGPR84SENP8
SCHEMBL7730013 0.92 THRB (0.36) DAOMAOBTHRBTAAR1PSMB5
SCHEMBL7730440 0.91 THRB (0.39) DAOTHRBPPARAPPARDPPARG
SCHEMBL7731652 0.91 MAOB (0.39) MAOBTHRBTAAR1PPARAPPARD
SCHEMBL7730397 0.91 DAO (0.33) DAOPPARAPPARDPPARG
SCHEMBL7732825 0.91 TAAR1 (0.37) DAOMAOBTHRBTAAR1PSMB5
SCHEMBL7730393 0.89 MAOB (0.34) DAOMAOBTHRBTAAR1GPR84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed