SCHEMBL7730459

SCHEMBL7730459

CCCc1cc(F)c(C(F)(F)Oc2ccc(CCc3cc(F)c(C(F)(F)F)c(F)c3)cc2)c(F)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAO P14920 2/20 0.38
THRB P10828 1/20 0.36
GPR84 Q9NQS5 2/20 0.35
TUBB4A P04350 1/20 0.32
TUBB P07437 1/20 0.32
TUBA3C P0DPH7 1/20 0.32
TUBA1B P68363 1/20 0.32
TUBA4A P68366 1/20 0.32
TUBB4B P68371 1/20 0.32
TUBB3 Q13509 1/20 0.32
TUBB2A Q13885 1/20 0.32
TUBB8 Q3ZCM7 1/20 0.32
TUBA3E Q6PEY2 1/20 0.32
TUBA1A Q71U36 1/20 0.32
TUBA1C Q9BQE3 1/20 0.32
TUBB6 Q9BUF5 1/20 0.32
TUBB2B Q9BVA1 1/20 0.32
TUBB1 Q9H4B7 1/20 0.32
SENP8 Q96LD8 1/20 0.32
SENP7 Q9BQF6 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7732213 0.92 DAO (0.36) DAOTHRBGPR84SENP8SENP7
SCHEMBL7735067 0.92 DAO (0.36) DAOTHRBGPR84PPARGPPARA
SCHEMBL7730765 0.92 DAO (0.38) DAOGPR84TUBB4ATUBBTUBA3C
SCHEMBL7734936 0.92 THRB (0.36) DAOTHRBGPR84TUBB4ATUBB
SCHEMBL7732086 0.91 THRB (0.40) DAOTHRBALDH1A1PPARGPPARA
SCHEMBL7735137 0.90 DAO (0.35) DAOTHRBRAB9APPARGPPARA
SCHEMBL7722745 0.90 DAO (0.36) DAOTHRBGPR84PPARGPPARA
SCHEMBL7730013 0.89 THRB (0.36) DAOTHRBSENP8SENP7SENP6
SCHEMBL7723224 0.88 DAO (0.38) DAO
SCHEMBL7732810 0.88 DAO (0.37) DAOTHRBGPR84TUBB4ATUBB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed