Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.31 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.31 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7732726 | 0.90 | ALDH1A1 (0.35) | L3MBTL1ALDH1A1EPHX1HSD11B1EPHX2 | |
| Bicarbonate SCHEMBL7732891 | 0.87 | ALDH1A1 (0.38) | L3MBTL1ALDH1A1EPHX1HSD11B1EPHX2 | |
| Bicarbonate SCHEMBL7739293 | 0.87 | ALDH1A1 (0.38) | L3MBTL1ALDH1A1EPHX1HSD11B1EPHX2 | |
| SCHEMBL7739288 | 0.77 | L3MBTL1 (0.38) | L3MBTL1ALDH1A1EPHX1HSD11B1TSHR | |
| SCHEMBL3001577 | 0.66 | — | — | |
| SCHEMBL2999577 | 0.66 | — | — | |
| SCHEMBL16314093 | 0.64 | HSD11B1 (0.44) | L3MBTL1ALDH1A1HSD11B1TSHRSCN1A | |
| SCHEMBL9141081 | 0.64 | GRIN2D (0.38) | TSHRTHRB | |
| SCHEMBL9146797 | 0.63 | HSD11B1 (0.33) | L3MBTL1ALDH1A1EPHX1HSD11B1EPHX2 | |
| SCHEMBL4814394 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410748-B1 | Alicycli c group-containing monomer | KABUSHIKI KAISHA TOSHIBA (JP) | 2002-06-25 | — | — | US | disclosed |
| US-6291129-B1 | LIGHT SENSITIVE ELEMENT WITH UNSATURATED POLYMERS | KABUSHIKI KAISHA TOSHIBA (JP) | 2001-09-18 | — | — | US | disclosed |