SCHEMBL7733331

SCHEMBL7733331

CCCCCc1ccc(C(F)(F)Oc2ccc(CCc3ccc(OC(F)F)c(F)c3)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 2/20 0.38
S1PR3 Q99500 1/20 0.38
CACNA1H O95180 1/20 0.34
PPARG P37231 2/20 0.34
PPARA Q07869 2/20 0.34
HTR2A P28223 1/20 0.33
PSEN1 P49768 1/20 0.33
BACE1 P56817 1/20 0.33
FAAH O00519 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7735808 0.97 S1PR1 (0.40) S1PR1S1PR3CACNA1HPPARGPPARA
SCHEMBL7732575 0.96 S1PR1 (0.35) S1PR1S1PR3CACNA1HPPARGPPARA
SCHEMBL7730786 0.94 HTR2A (0.35) S1PR1S1PR3CACNA1HPPARGPPARA
SCHEMBL7731646 0.92 CACNA1H (0.36) S1PR1S1PR3CACNA1HPPARGBACE1
SCHEMBL7722798 0.92 S1PR1 (0.37) S1PR1S1PR3CACNA1HPPARGPPARA
SCHEMBL7729545 0.92 RARB (0.43) S1PR1S1PR3CACNA1H
SCHEMBL7730764 0.91 S1PR1 (0.38) S1PR1S1PR3CACNA1HPPARGPPARA
SCHEMBL7731641 0.90 CACNA1H (0.36) S1PR1S1PR3CACNA1HPPARA
SCHEMBL7722503 0.88 RARB (0.39) S1PR1S1PR3CACNA1HPPARGPPARA
SCHEMBL7734852 0.88 HTR2A (0.34) S1PR1PPARGPPARAHTR2ABACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed