SCHEMBL7729545

SCHEMBL7729545

CCCCCc1ccc(C(F)(F)Oc2ccc(-c3ccc(OC(F)F)c(F)c3)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARB P10826 6/20 0.43
RARA P10276 2/20 0.43
RARG P13631 1/20 0.43
S1PR1 P21453 2/20 0.38
MGLL Q99685 3/20 0.33
CACNA1H O95180 1/20 0.33
TSHR P16473 1/20 0.33
HSD17B10 Q99714 1/20 0.33
S1PR3 Q99500 1/20 0.33
CYP17A1 P05093 1/20 0.33
MEN1 O00255 1/20 0.33
USP2 O75604 1/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
CYP3A4 P08684 1/20 0.33
MAPK1 P28482 1/20 0.33
CASP1 P29466 1/20 0.33
KMT2A Q03164 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
SLCO1B3 Q9NPD5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7722503 0.97 RARB (0.39) RARBRARARARGS1PR1MGLL
SCHEMBL7732575 0.94 S1PR1 (0.35) RARBRARARARGS1PR1CACNA1H
SCHEMBL7722493 0.93 S1PR1 (0.36) RARBRARARARGS1PR1CACNA1H
SCHEMBL7730786 0.92 HTR2A (0.35) RARBRARARARGS1PR1CACNA1H
SCHEMBL7733331 0.92 S1PR1 (0.38) S1PR1CACNA1HS1PR3
SCHEMBL7722798 0.90 S1PR1 (0.37) S1PR1CACNA1HS1PR3
SCHEMBL7730764 0.89 S1PR1 (0.38) S1PR1CACNA1HS1PR3
SCHEMBL7731179 0.88 RARB (0.41) RARBRARARARGTSHRHSD17B10
SCHEMBL7731908 0.88 RARB (0.46) RARBRARARARGS1PR1TSHR
SCHEMBL7735808 0.88 S1PR1 (0.40) S1PR1CACNA1HS1PR3SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed
EP-0786445-A1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORPORATION (JP) 1997-07-30 EP disclosed