SCHEMBL7735808

SCHEMBL7735808

CCCCc1ccc(C(F)(F)Oc2ccc(CCc3ccc(OC(F)F)c(F)c3)cc2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 1/20 0.40
S1PR3 Q99500 1/20 0.40
PSEN1 P49768 2/20 0.36
CETP P11597 1/20 0.35
CACNA1H O95180 1/20 0.35
PPARG P37231 2/20 0.33
PTGES O14684 2/20 0.33
ALOX5 P09917 2/20 0.33
BACE1 P56817 1/20 0.32
GLA P06280 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
PPARA Q07869 1/20 0.32
FFAR1 O14842 1/20 0.32
CYP2C9 P11712 1/20 0.32
KCNH2 Q12809 1/20 0.32
CACNA1C Q13936 1/20 0.32
PDE4A P27815 1/20 0.32
PDE4B Q07343 1/20 0.32
PDE4C Q08493 1/20 0.32
PDE4D Q08499 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7733331 0.97 S1PR1 (0.38) S1PR1S1PR3PSEN1CACNA1HPPARG
SCHEMBL7722798 0.95 S1PR1 (0.37) S1PR1S1PR3PSEN1CETPCACNA1H
SCHEMBL7730764 0.94 S1PR1 (0.38) S1PR1S1PR3PSEN1CETPCACNA1H
SCHEMBL7731646 0.93 CACNA1H (0.36) S1PR1S1PR3CETPCACNA1HPPARG
SCHEMBL7732575 0.92 S1PR1 (0.35) S1PR1S1PR3PSEN1CETPCACNA1H
SCHEMBL7722503 0.91 RARB (0.39) S1PR1S1PR3PSEN1CETPCACNA1H
SCHEMBL7731641 0.91 CACNA1H (0.36) S1PR1S1PR3CACNA1HPPARAFFAR1
SCHEMBL7730786 0.91 HTR2A (0.35) S1PR1S1PR3PSEN1CETPCACNA1H
SCHEMBL7729274 0.89 FFAR1 (0.36) S1PR1S1PR3CETPCACNA1HPPARG
SCHEMBL7729545 0.88 RARB (0.43) S1PR1S1PR3CACNA1HSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed