Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10153121 | 0.78 | NR2E1 (0.40) | EGLN2CYP2E1CYP2A6NR2E1PSEN1 | |
| SCHEMBL9868208 | 0.77 | EGLN2 (0.45) | ALDH1A1EGLN2CYP2E1CYP2A6PSEN1 | |
| SCHEMBL25343812 | 0.74 | MAOA (0.45) | ALDH1A1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL20168525 | 0.74 | KCNJ1 (0.39) | EGLN2GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8032866 | 0.74 | ALDH1A3 (0.50) | ALDH1A1EGLN2CYP2A6PSEN1PSEN2 | |
| SCHEMBL30444602 | 0.74 | KCNJ1 (0.39) | EGLN2GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL10153120 | 0.74 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL6124667 | 0.72 | MAOA (0.38) | EGLN2CYP2E1CYP2A6PSEN1PSEN2 | |
| SCHEMBL9700802 | 0.72 | NR2E1 (0.46) | GRIA1GRIA2GRIA3GRIA4CYP2E1 | |
| SCHEMBL7738305 | 0.71 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137320-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137320-A1 | GAMMA SECRETASE MODULATORS | BACE1, BACE2, GSAP | ALDH1A1 1823/4885SMN1; SMN2 1408/4885EGLN2 2709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.