Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | HPGD | P15428 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7734542 | 0.80 | ALDH1A1 (0.35) | HSD17B10ALDH1A1PTGS1PTGS2SMARCA2 | |
| Hydrochloric Acid SCHEMBL3669142 | 0.79 | SMARCA2 (0.35) | HSD17B10ALDH1A1PTGS1PTGS2SMARCA2 | |
| Hydrochloric Acid SCHEMBL30312734 | 0.78 | PTGS1 (0.39) | HSD17B10ALDH1A1PTGS1PTGS2SMARCA2 | |
| Hydrochloric Acid SCHEMBL8080008 | 0.75 | KDM4E (0.32) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| Hydrochloric Acid SCHEMBL7059218 | 0.72 | CHRM2 (0.32) | HSD17B10ALDH1A1KDM4EHPGDMEN1 | |
| Hydrochloric Acid SCHEMBL28670211 | 0.72 | ADORA2A (0.34) | HSD17B10ALDH1A1PTGS1PTGS2ADORA2A | |
| Hydrochloric Acid SCHEMBL7065728 | 0.71 | ALDH1A1 (0.34) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7732776 | 0.68 | ADORA2A (0.34) | HSD17B10ALDH1A1PTGS1PTGS2SMARCA2 | |
| Hydrochloric Acid SCHEMBL6902882 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL15863273 | 0.67 | SMARCA2 (0.36) | HSD17B10ALDH1A1PTGS1PTGS2SMARCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479646-B1 | Metallocene compounds having indenyl ligand and catalysts for olefin polymerization containing the same | CHISSO CORPORATION (JP) | 2002-11-12 | — | — | US | disclosed |