Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | BLM | P54132 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | CASP7 | P55210 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3669142 | 0.90 | SMARCA2 (0.35) | ADORA2AADORA2BADORA1HSD17B10KDM4E | |
| Hydrochloric Acid SCHEMBL5951554 | 0.80 | HTR1A (0.33) | NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7061934 | 0.79 | KDM4E (0.33) | ADORA2AHSD17B10KDM4EALDH1A1MEN1 | |
| SCHEMBL7732779 | 0.78 | KDM4E (0.33) | ADORA2AADORA2BADORA1HSD17B10KDM4E | |
| Hydrochloric Acid SCHEMBL30312734 | 0.76 | PTGS1 (0.39) | ADORA2AADORA2BADORA1HSD17B10KDM4E | |
| Hydrochloric Acid SCHEMBL6902799 | 0.75 | CHRM2 (0.36) | HSD17B10ALDH1A1HPGDCASP1CASP7 | |
| Hydrochloric Acid SCHEMBL15863273 | 0.75 | SMARCA2 (0.36) | ADORA2AADORA2BADORA1HSD17B10KDM4E | |
| Hydrochloric Acid SCHEMBL7065728 | 0.74 | ALDH1A1 (0.34) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7730993 | 0.74 | SMARCA2 (0.35) | ADORA2AADORA2BADORA1HSD17B10KDM4E | |
| Hydrochloric Acid SCHEMBL7730635 | 0.74 | SMARCA2 (0.35) | ADORA2AADORA2BADORA1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479646-B1 | Metallocene compounds having indenyl ligand and catalysts for olefin polymerization containing the same | CHISSO CORPORATION (JP) | 2002-11-12 | — | — | US | disclosed |