Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 8/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.50 |
| ▸ | PARG | Q86W56 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739342 | 0.86 | KDM4E (0.52) | GRIN1GRIN2BKMT2AMEN1MAPT | |
| SCHEMBL7742336 | 0.84 | LMNA (0.57) | KMT2AMEN1MAPTKDM4E | |
| SCHEMBL21113764 | 0.83 | GRIN1 (0.52) | GRIN1GRIN2BHSD17B10KDM4E | |
| SCHEMBL7734611 | 0.75 | POLB (0.40) | KMT2AMEN1MAPTRXFP1KDM4E | |
| SCHEMBL21113905 | 0.75 | GRIN1 (0.49) | GRIN1GRIN2BPARGHSD17B10KDM4E | |
| SCHEMBL7734767 | 0.74 | KDM4E (0.40) | GRIN1GRIN2BKMT2AMEN1MAPT | |
| SCHEMBL4077298 | 0.74 | CYP1A2 (0.60) | PARGDAOKMT2AMEN1 | |
| SCHEMBL21115761 | 0.73 | GRIN1 (0.54) | GRIN1GRIN2BKMT2AMEN1HSD17B10 | |
| SCHEMBL7739420 | 0.72 | MAPT (0.50) | KMT2AMEN1MAPTHSD17B10KDM4E | |
| SCHEMBL7734586 | 0.72 | ALDH1A1 (0.42) | KMT2AMEN1MAPTMAPK1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420410-B1 | ADMINISTERING N,N'-SUBSTITUTED BENZIMIDAZOL-2-ONES TO INDUCE APOPTOSIS IN NEOPLASTIC CELLS BUT NOT NORMAL CELLS; ANTICANCER, ANTITUMOR AGENT | CELL PATHWAYS, INC. | 2002-07-16 | — | — | US | disclosed |