Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.61 |
| ▸ | MMP12 | P39900 | 1/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.48 |
| ▸ | NAAA | Q02083 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7735115 | 0.89 | HDAC1 (0.54) | MMP2MMP12FFAR1FFAR4L3MBTL1 | |
| SCHEMBL7734911 | 0.85 | MMP2 (0.53) | MMP2MMP12FFAR1FFAR4L3MBTL1 | |
| SCHEMBL6936308 | 0.79 | MMP2 (0.67) | MMP2MMP12FFAR1FFAR4 | |
| SCHEMBL7740315 | 0.78 | S1PR1 (0.62) | MAPK1DRD2DRD4DRD3NAAA | |
| SCHEMBL7741075 | 0.78 | MAPK1 (0.55) | MMP2MMP12MAPK1DRD2DRD4 | |
| SCHEMBL7740826 | 0.77 | MAPK1 (0.60) | FFAR1MAPK1EPHX2L3MBTL1CA1 | |
| SCHEMBL15480468 | 0.77 | MAPK1 (0.84) | MAPK1NAAAL3MBTL1CA1CA2 | |
| SCHEMBL7741009 | 0.76 | MAPK1 (0.59) | MAPK1DRD2DRD4DRD3L3MBTL1 | |
| SCHEMBL16151544 | 0.76 | NAAA (0.72) | MMP2MMP12DRD2DRD4DRD3 | |
| SCHEMBL27722036 | 0.76 | MAPK1 (0.67) | MAPK1NAAAL3MBTL1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | disclosed |