Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.47 |
| ▸ | HTR2A | P28223 | 4/20 | 0.45 |
| ▸ | HTR2C | P28335 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7734067 | 0.81 | MTNR1A (0.41) | MTNR1AMTNR1BHTR2AHTR2C | |
| SCHEMBL12450045 | 0.70 | HTR2A (0.74) | MTNR1AMTNR1BHTR2AHTR2C | |
| SCHEMBL5796602 | 0.66 | KDM4E (0.39) | MTNR1AMTNR1BHTR2AHTR2CKDM4E | |
| SCHEMBL6325423 | 0.61 | MCL1 (0.33) | HTR2AHTR2C | |
| SCHEMBL7734107 | 0.60 | ICMT (0.50) | HTR2AKDM4EMPO | |
| SCHEMBL2349253 | 0.59 | HTR2A (0.69) | MTNR1AMTNR1BHTR2AHTR2C | |
| SCHEMBL21252671 | 0.58 | MAPT (0.35) | — | |
| SCHEMBL5238108 | 0.57 | HTR2A (0.42) | MTNR1AMTNR1BHTR2AHTR2CMPO | |
| SCHEMBL20044938 | 0.57 | TYR (0.39) | KDM4EMPO | |
| SCHEMBL31552629 | 0.56 | KMT2A (0.35) | KDM4ESMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828325-B2 | A benzoxazolopiperazine derivative useful for treating Parkinson's diseases, schizophrenia, anxiety and depression | SOLVAY PHARMACEUTICALS B.V. (CH) | 2004-12-07 | — | — | US | disclosed |