SCHEMBL7735237

SCHEMBL7735237

CCc1ccc(C(F)(F)Oc2cc(F)c(F)c(F)c2)c(F)c1

nearest known ligand 0.33

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.33
MAOB P27338 1/20 0.33
KIF11 P52732 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2A6 P11509 1/20 0.33
PDE2A O00408 2/20 0.31
P2RX7 Q99572 1/20 0.31
TSHR P16473 1/20 0.31
DAO P14920 1/20 0.30
RIPK1 Q13546 1/20 0.30
TRPA1 O75762 1/20 0.30
PDK2 Q15119 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7735122 0.92 TSHR (0.32) FFAR1MAOBKIF11P2RX7TSHR
SCHEMBL14749513 0.90 FFAR1 (0.32) FFAR1KIF11CYP1A2CYP2A6PDE2A
SCHEMBL7722606 0.89 DAO (0.36) FFAR1MAOBP2RX7TSHRDAO
SCHEMBL19711843 0.89 KIF11 (0.44) FFAR1KIF11
SCHEMBL7730346 0.88 KIF11 (0.34) FFAR1KIF11CYP1A2CYP2A6DAO
SCHEMBL7731510 0.88 DAO (0.34) FFAR1MAOBKIF11DAOPDK2
SCHEMBL14749512 0.88 TSHR (0.38) FFAR1KIF11CYP1A2CYP2A6TSHR
SCHEMBL7731319 0.88 KIF11 (0.40) FFAR1MAOBKIF11TSHR
SCHEMBL7731627 0.87 PDE2A (0.34) FFAR1KIF11PDE2ATSHR
SCHEMBL7722692 0.86 SKP2 (0.35) DAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed
US-5858270-A Difluorooxymethane derivative and liquid crystal composition CHISSO CORPORATION (JP) 1999-01-12 US disclosed
EP-0786445-A1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORPORATION (JP) 1997-07-30 EP disclosed