SCHEMBL7735403

SCHEMBL7735403

COc1cccc(Cl)c1P(=O)(C(=O)c1ccccc1)C(=O)c1c(C)cc(C)c(C)c1C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PYGL P06737 1/20 0.37
PTGS2 P35354 1/20 0.36
MRGPRX4 Q96LA9 1/20 0.36
TOP1 P11387 1/20 0.36
MEN1 O00255 3/20 0.36
ALDH1A1 P00352 3/20 0.36
KMT2A Q03164 3/20 0.36
KDM4E B2RXH2 2/20 0.36
POLB P06746 1/20 0.36
NPC1 O15118 5/20 0.35
RAB9A P51151 5/20 0.35
ATM Q13315 1/20 0.35
PDE4D Q08499 1/20 0.35
KCNK3 O14649 1/20 0.35
KCNK9 Q9NPC2 1/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
FABP4 P15090 1/20 0.35
HTT P42858 1/20 0.35
KCNH2 Q12809 1/20 0.35
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7182401 0.89 MEN1 (0.40) PYGLMEN1ALDH1A1KMT2AKDM4E
SCHEMBL7188630 0.88 TRPM4 (0.41) ALDH1A1KMT2APOLBNPC1RAB9A
SCHEMBL7181146 0.88 TP53 (0.36) MEN1ALDH1A1KMT2AKDM4EPOLB
SCHEMBL7174658 0.87 ATM (0.38) TOP1MEN1ALDH1A1KMT2AKDM4E
SCHEMBL7175566 0.86 TRPM4 (0.41) ALDH1A1NPC1RAB9AATMFABP4
SCHEMBL7178228 0.86 CA12 (0.44) PYGLALDH1A1NPC1RAB9AATM
SCHEMBL7186756 0.86 CA12 (0.41) PYGLMEN1ALDH1A1KMT2ANPC1
SCHEMBL7189982 0.86 ALDH1A1 (0.37) PYGLMEN1ALDH1A1KMT2AKDM4E
SCHEMBL7723205 0.84 EPHX1 (0.40) MEN1KMT2AKDM4ENPC1RAB9A
SCHEMBL7175979 0.83 ABCG2 (0.42) MEN1ALDH1A1KMT2APOLBNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 PYGL 4038/4885PTGS2 3871/4885MRGPRX4 4163/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.