SCHEMBL7188630

SCHEMBL7188630

COc1cccc(Cl)c1P(=O)(C(=O)c1ccccc1)C(=O)c1c(C)cccc1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPM4 Q8TD43 1/20 0.41
ATM Q13315 2/20 0.40
FABP4 P15090 1/20 0.38
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA7 P43166 1/20 0.38
CA9 Q16790 1/20 0.38
CA14 Q9ULX7 1/20 0.38
RAB9A P51151 4/20 0.38
NPC1 O15118 3/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C19 P33261 1/20 0.38
ALDH1A1 P00352 1/20 0.36
MAPT P10636 1/20 0.36
TAS1R3 Q7RTX0 1/20 0.36
TAS1R1 Q7RTX1 1/20 0.36
TAS1R2 Q8TE23 1/20 0.36
KCNK3 O14649 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7175566 0.96 TRPM4 (0.41) TRPM4ATMFABP4CA12CA1
SCHEMBL7182401 0.92 MEN1 (0.40) ATMFABP4RAB9ANPC1ALDH1A1
SCHEMBL7186756 0.91 CA12 (0.41) ATMFABP4CA12CA1CA2
SCHEMBL7178228 0.91 CA12 (0.44) ATMFABP4CA12CA1CA2
SCHEMBL7182181 0.90 ATM (0.42) TRPM4ATMFABP4CA12CA1
SCHEMBL7177270 0.89 ATM (0.41) TRPM4ATMFABP4CA12CA1
SCHEMBL7189982 0.89 ALDH1A1 (0.37) ATMFABP4RAB9ANPC1ALDH1A1
SCHEMBL7735403 0.88 PYGL (0.37) ATMFABP4RAB9ANPC1ALDH1A1
SCHEMBL7182450 0.87 FABP3 (0.39) TRPM4FABP4ALDH1A1MAPTPOLB
SCHEMBL7178067 0.87 ALDH1A1 (0.39) ATMRAB9ANPC1ALDH1A1TAS1R3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 TRPM4 3654/4885ATM 2823/4885FABP4 4550/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 TRPM4 3840/4885ATM 2935/4885FABP4 4256/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.