4,4'-Dihydroxychalcone

4,4'-Dihydroxychalcone

SCHEMBL773589

O=C(C=Cc1ccc(O)cc1)c1ccc(O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F3 P13726 3/20 1.00
MAPT P10636 6/20 0.82
RAB9A P51151 4/20 0.82
MAOB P27338 3/20 0.82
MAOA P21397 2/20 0.82
ESR1 P03372 1/20 0.82
ESR2 Q92731 1/20 0.82
CXCL12 P48061 1/20 0.82
POLB P06746 1/20 0.82
KMT2A Q03164 4/20 0.81
MEN1 O00255 3/20 0.81
CYP3A4 P08684 2/20 0.81
HSPD1 P10809 2/20 0.81
HSPE1 P61604 2/20 0.81
CYP1B1 Q16678 2/20 0.81
PKM P14618 1/20 0.81
NFKB1 P19838 1/20 0.81
NFKB2 Q00653 1/20 0.81
RELA Q04206 1/20 0.81
ALDH2 P05091 1/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25236411 1.00 F3 (1.00) F3MAPTRAB9AMAOBMAOA
SCHEMBL10703657 1.00 F3 (1.00) F3MAPTRAB9AMAOBMAOA
SCHEMBL10787169 1.00 F3 (1.00) F3MAPTRAB9AMAOBMAOA
SCHEMBL25211913 1.00 F3 (1.00) F3MAPTRAB9AMAOBMAOA
4,4'-Dihydroxychalcone SCHEMBL773588 1.00 F3 (1.00) F3MAPTRAB9AMAOBMAOA
SCHEMBL25223420 1.00 F3 (1.00) F3MAPTRAB9AMAOBMAOA
4,4'-Dihydroxychalcone SCHEMBL25202156 1.00 F3 (1.00) F3MAPTRAB9AMAOBMAOA
SCHEMBL25208810 0.92 F3 (0.85) F3MAPTRAB9AMAOBMAOA
SCHEMBL12651351 0.92 F3 (0.85) F3MAPTRAB9AMAOBMAOA
4,4'-Dihydroxychalcone SCHEMBL9542070 0.92 KMT2A (0.96) F3MAPTRAB9AMAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 397 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250326839-A1 TREATMENT OF DISEASES RELATED TO COLONY-STIMULATING FACTOR 1 RECEPTOR DYSFUNCTION USING TREM2 AGONISTS VIGIL NEUROSCIENCE INC (US) 2025-10-23 US claimed
US-20250282866-A1 TREATMENT OF DISEASES RELATED TO ATP-BINDING CASSETTE TRANSPORTER 1 DYSFUNCTION USING TREM2 AGONISTS VIGIL NEUROSCIENCE INC (US) 2025-09-11 US claimed
EP-4255567-A1 TREATMENT OF DISEASES RELATED TO ATP-BINDING CASSETTE TRANSPORTER 1 DYSFUNCTION USING TREM2 AGONISTS Vigil Neuroscience, Inc. (US) 2023-10-11 EP claimed
US-20230082623-A1 TREATMENT OF DISEASES RELATED TO ATP-BINDING CASSETTE TRANSPORTER 1 DYSFUNCTION USING TREM2 AGONISTS VIGIL NEUROSCIENCE, INC. 2023-03-16 US claimed
WO-2022120390-A1 TREATMENT OF DISEASES RELATED TO ATP-BINDING CASSETTE TRANSPORTER 1 DYSFUNCTION USING TREM2 AGONISTS VIGIL NEUROSCIENCE, INC. (US) 2022-06-09 WO claimed
US-9877946-B2 Method for treating, managing, inhibiting, or preventing obesity Research & Business Foundation Sungkyunkwan University (KR) 2018-01-30 US claimed
US-20170087126-A1 COMPOSITION FOR INDUCING DIFFERENTIATION INTO BEIGE AND BROWN ADIPOCYTES AND METHOD OF INDUCING THE SAME RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVER SITY (KR) 2017-03-30 US claimed
US-9549908-B2 Composition for inducing differentiation into beige and brown adipocytes and method of inducing the same Research & Business Foundation Sungkyunkwan University, Ltd. (KR) 2017-01-24 US claimed
US-20150374643-A1 COMPOSITION FOR INDUCING DIFFERENTIATION INTO BEIGE AND BROWN ADIPOCYTES AND METHOD OF INDUCING THE SAME Research & Business Foundation Sungkyunkwan University (KR) 2015-12-31 US claimed
US-20120070515-A1 Composition Comprising the Extract of Anemarrhena Asphodeloides Bunge or the Compounds Isolated from the Same for Preventing and Treating Lipid Metabolism Disorder EWHA UNIVERSITY- INDUSTRY COLLABORATION FOUNDATION (KR) 2012-03-22 US claimed
US-5342904-A Polymer modified adducts of epoxy resins and active hydrogen containing compounds containing mesogenic moieties THE DOW CHEMICAL COMPANY (US) 1994-08-30 US claimed
US-5248740-A Thioepoxides, liquid crystal polymers THE DOW CHEMICAL COMPANY (US) 1993-09-28 US claimed
US-5235008-A Curable THE DOW CHEMICAL COMPANY (US) 1993-08-10 US claimed
US-5182340-A Molding materials having shorter gel time with aliphatic amine curing agents THE DOW CHEMICAL COMPANY (US) 1993-01-26 US claimed
US-5164464-A Liquid crystalline polymers, acrylated epoxy resins THE DOW CHEMICAL COMPANY (US) 1992-11-17 US claimed
US-4962163-A ADVANCED POLYEPOXIDES AND EPOXY RESINS MODIFIED BY AN UNSATURATED CARBOXYLIC ACID; CURED COATING AND FILMS HAVINGI IMPROVED TENSILE AND FLEXURAL STRENGTH AND MODULUS THE DOW CHEMICAL COMPANY (US) 1990-10-09 US claimed
EP-0379058-A2 Vinyl ester resins containing mesogenic/rigid rodlike moieties THE DOW CHEMICAL COMPANY (US) 1990-07-25 EP claimed
US-4877711-A DURABLE PRINTING PLATES FUJI PHOTO FILM CO., LTD. (JP) 1989-10-31 US claimed
US-4863835-A UNSATURATED POLYESTER, BENZYL ALCOHOL, TETRAHYDROFURFURYL ALCOHOL, ACID MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) 1989-09-05 US claimed
US-4279930-A Process for treating inflammation THE UPJOHN COMPANY (US) 1981-07-21 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170087126-A1 COMPOSITION FOR INDUCING DIFFERENTIATION INTO BEIGE AND BROWN ADIPOCYTES AND METHOD OF INDUCING THE SAME FABP4, PLIN1, PRDM7 F3 3585/4885MAPT 1236/4885RAB9A 4514/4885
US-20150374643-A1 COMPOSITION FOR INDUCING DIFFERENTIATION INTO BEIGE AND BROWN ADIPOCYTES AND METHOD OF INDUCING THE SAME FABP4, PLIN1, PRDM7 F3 3585/4885MAPT 1236/4885RAB9A 4514/4885
US-20120070515-A1 Composition Comprising the Extract of Anemarrhena Asphodeloides Bunge or the Compounds Isolated from the Same for Preventing and Treating Lipid Metabolism Disorder FABP4, ACACB, LIPC F3 3182/4885MAPT 2597/4885RAB9A 2255/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.