Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 4/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | PYGL | P06737 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8582012 | 0.77 | SLC6A12 (0.41) | SIGMAR1PYGL | |
| SCHEMBL11287590 | 0.75 | TSHR (0.49) | MTNR1AMTNR1BMEN1CYP1A2CYP3A4 | |
| SCHEMBL11287585 | 0.75 | TSHR (0.49) | MTNR1AMTNR1BMEN1CYP1A2CYP3A4 | |
| SCHEMBL11291868 | 0.75 | TSHR (0.49) | MTNR1AMTNR1BMEN1CYP1A2CYP3A4 | |
| SCHEMBL14957322 | 0.73 | GRM2 (0.40) | GRM2GRM1GRM4GRM3SIGMAR1 | |
| SCHEMBL8296922 | 0.72 | PYGL (0.41) | MTNR1AMTNR1BMEN1CYP1A2CYP3A4 | |
| SCHEMBL8638015 | 0.70 | FFAR1 (0.47) | MTNR1AMTNR1B | |
| SCHEMBL14978978 | 0.70 | FFAR1 (0.47) | MTNR1AMTNR1B | |
| SCHEMBL24650858 | 0.68 | PYGL (0.42) | SIGMAR1PYGL | |
| SCHEMBL2067933 | 0.68 | PYGL (0.42) | MEN1TSHRKMT2APYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699909-B1 | MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS | PRESCIENT NEUROPHARMA INC. (CA) | 2004-03-02 | — | — | US | disclosed |
| US-6699909-B1 | MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS | PRESCIENT NEUROPHARMA INC. (CA) | 2004-03-02 | — | — | US | disclosed |