Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8379857 | 0.80 | TSHR (0.46) | TSHRCYP1A2KCNN4ALDH1A1TAAR1 | |
| SCHEMBL1829396 | 0.76 | TSHR (0.52) | TSHRCYP1A2KCNN4ALDH1A1TAAR1 | |
| SCHEMBL6062610 | 0.74 | TAAR1 (0.52) | TSHRCYP1A2KCNN4ALDH1A1TAAR1 | |
| SCHEMBL6685341 | 0.74 | TSHR (0.50) | TSHRCYP1A2KCNN4ALDH1A1TAAR1 | |
| SCHEMBL7409166 | 0.74 | TSHR (0.50) | TSHRCYP1A2KCNN4ALDH1A1TAAR1 | |
| SCHEMBL8365376 | 0.74 | TSHR (0.50) | TSHRCYP1A2KCNN4ALDH1A1TAAR1 | |
| SCHEMBL819164 | 0.74 | TSHR (0.65) | TSHRCYP1A2KCNN4ALDH1A1TAAR1 | |
| SCHEMBL439212 | 0.72 | KIF11 (0.46) | TSHRCYP1A2KCNN4ALDH1A1TAAR1 | |
| SCHEMBL2102354 | 0.72 | TSHR (0.48) | TSHRCYP1A2KCNN4ALDH1A1TAAR1 | |
| SCHEMBL11814132 | 0.72 | TSHR (0.48) | TSHRCYP1A2KCNN4ALDH1A1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1198456-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2002-04-24 | — | — | EP | disclosed |
| WO-2001009096-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2001-02-08 | — | — | WO | disclosed |
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| CN-1216986-A | Isoxazole derivatives | SANKYO CO (JP) | 1999-05-19 | — | — | CN | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |
| EP-0193065-B1 | Morpholine derivatives, processes for their production and their use as fungicides | BASF AG (DE) | 1995-08-23 | — | — | EP | disclosed |
| US-5376684-A | Aminobutyric acid antagonist; antiepileptic agent | CIBA-GEIGY CORPORATION (US) | 1994-12-27 | — | — | US | disclosed |
| EP-0224163-B1 | PROPYL AMINES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES | BASF Aktiengesellschaft (DE) | 1991-10-16 | — | — | EP | disclosed |
| US-4967003-A | Propylamines, and their use as fungicides | BASF AKTIENGESELLSCHAFT (DE) | 1990-10-30 | — | — | US | disclosed |
| US-4758564-A | Ether and thioether amines and their use as fungicides | BASF AKTIENGESELLSCHAFT (DE) | 1988-07-19 | — | — | US | disclosed |
| US-4732989-A | INTERMEDIATES FOR BACTERICIDES | G. D. SEARLE & CO. (US) | 1988-03-22 | — | — | US | disclosed |
| EP-0224163-A2 | Propyl amines, process for their preparation and their use as fungicides | BASF Aktiengesellschaft (DE) | 1987-06-03 | — | — | EP | disclosed |
| CN-86107151-A | The dopamine-inhibitor | — | 1987-05-13 | — | — | CN | disclosed |
| US-4661602-A | ANTIANAEROBIC AGENTS | G. D. SEARLE & CO. (US) | 1987-04-28 | — | — | US | disclosed |
| EP-0193065-A1 | Morpholine derivatives, processes for their production and their use as fungicides | BASF Aktiengesellschaft (DE) | 1986-09-03 | — | — | EP | disclosed |