SCHEMBL7737301

SCHEMBL7737301

Cc1cc(F)c(C(=O)O)c(F)c1-c1cc(F)c(F)c(F)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 2/20 0.37
CES2 O00748 1/20 0.35
CES1 P23141 1/20 0.35
CYP3A4 P08684 1/20 0.34
ACHE P22303 1/20 0.34
MEN1 O00255 5/20 0.34
KMT2A Q03164 5/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
CRHBP P24387 1/20 0.34
CRHR2 Q13324 1/20 0.34
KMO O15229 2/20 0.34
MAPK1 P28482 2/20 0.34
POLB P06746 1/20 0.34
CA1 P00915 2/20 0.33
CA2 P00918 2/20 0.33
CA4 P22748 2/20 0.33
DHODH Q02127 2/20 0.33
ALB P02768 1/20 0.33
TTR P02766 1/20 0.33
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7736470 0.80 CES2 (0.33) CES2CES1CA1CA2CA4
SCHEMBL4438092 0.77 MEN1 (0.43) NOTUMCYP3A4ACHEMEN1KMT2A
SCHEMBL24499403 0.77 DHODH (0.44) NOTUMMEN1KMT2ASMN1; SMN2CRHBP
SCHEMBL7728379 0.76 PTPN1 (0.42) CES2CES1
SCHEMBL7736557 0.75 RARB (0.40) KMODHODH
SCHEMBL7736708 0.74 FFAR4 (0.38) MEN1KMT2ASMN1; SMN2DHODHALDH1A1
SCHEMBL6045020 0.74 CA1 (0.45) NOTUMCES2CES1CYP3A4ACHE
SCHEMBL4438095 0.74 CYP3A4 (0.45) NOTUMCES2CES1CYP3A4ACHE
SCHEMBL7728350 0.72 SCN9A (0.33) NOTUM
SCHEMBL7728347 0.72 SCN9A (0.33) NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6468606-B1 LOW VISCOSITY, HIGH DIELECTRIC ANISOTROPY, LOW OPTICAL ANISOTROPY, EXCELLENT LOW TEMPERATURE COMPATIBILITY WITH OTHER LIQUID CRYSTALLINE COMPOUNDS; 3,4,5-TRIFLUOROPHENYL-(2-FLUORO-4-(TRANS-4-PROPYLCYCLOHEXYL))BENZOATE CHISSO CORPORATION (JP) 2002-10-22 US disclosed
EP-0808825-B1 PHENYL BENZOATE DERIVATIVES AND LIQUID CRYSTAL COMPOSITIONS CHISSO CORP (JP) 2001-09-12 EP disclosed
US-5922243-A LOW VISCOSITY, HIGH DIELECTRIC AND LOW OPTICAL ANISOTROPY, EXCELLENT COMPATIBILITY CHISSO CORPORATION (JP) 1999-07-13 US disclosed
EP-0808825-A1 PHENYL BENZOATE DERIVATIVES AND LIQUID CRYSTAL COMPOSITIONS CHISSO CORPORATION (JP) 1997-11-26 EP disclosed