SCHEMBL7737468

SCHEMBL7737468

C#CCOc1cccc2ncoc12

nearest known ligand 0.42

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.42
CYP2A6 P11509 1/20 0.42
LOXL2 Q9Y4K0 1/20 0.42
MAOB P27338 8/20 0.40
MAPT P10636 1/20 0.38
MTNR1A P48039 2/20 0.35
MTNR1B P49286 2/20 0.35
HTR2A P28223 1/20 0.34
HTR2C P28335 1/20 0.34
MAOA P21397 4/20 0.34
POLB P06746 1/20 0.33
MAPK1 P28482 1/20 0.33
HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL645949 0.74 NQO2 (0.47) CYP2A6MAPTMTNR1AMTNR1BHTR2A
SCHEMBL20541051 0.72 TXNRD1 (0.43) CYP3A4CYP2A6LOXL2MAOBMAPT
SCHEMBL30663731 0.70 MAPT (0.56) CYP3A4CYP2A6LOXL2MAOBMAPT
SCHEMBL10347560 0.70 MAPT (0.56) CYP3A4CYP2A6LOXL2MAOBMAPT
SCHEMBL30506059 0.70 ELANE (0.40) MTNR1AMTNR1BHTR2AHTR2C
SCHEMBL28187711 0.70 SCN9A (0.40) MAPTMTNR1AMTNR1BHTR2AHTR2C
SCHEMBL19038909 0.69 CYP3A4 (0.57) CYP3A4CYP2A6LOXL2MAOBMAPT
SCHEMBL3198497 0.69 CYP3A4 (0.49) CYP3A4CYP2A6LOXL2MAOBMAPT
SCHEMBL905744 0.69 MTNR1A (0.42) MAPTMTNR1AMTNR1BHTR2AHTR2C
SCHEMBL19690941 0.69 CYP3A4 (0.47) CYP3A4CYP2A6LOXL2MAOBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6372770-B1 TREATING A MAMMAL SUFFERING FROM A DISEASE STATE SELECTED FROM THE GROUP CONSISTING OF ASTHMA, ALLERGIES, INFLAMMATION, DEPRESSION, DEMENTIA, ATOPIC DISEASES, RHINITIS AND DISEASE STATES ASSOCIATED WITH ABNORMALLY HIGH PHYSIOLOGICAL LEVELS OF EURO-CELTIQUE, S.A. 2002-04-16 US disclosed