Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.51 |
| ▸ | NAMPT | P43490 | 6/20 | 0.47 |
| ▸ | CCR8 | P51685 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MDM4 | O15151 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4976161 | 0.79 | NPSR1 (0.61) | TP53KMT2ANPSR1HSD17B10ALDH1A1 | |
| SCHEMBL28189189 | 0.75 | KMT2A (0.76) | TP53KMT2ANPSR1HSD17B10ALDH1A1 | |
| SCHEMBL7295905 | 0.71 | KMT2A (0.60) | TP53KMT2ANPSR1HSD17B10ALDH1A1 | |
| SCHEMBL2339343 | 0.70 | ALDH1A1 (1.00) | TP53KMT2ANPSR1HSD17B10ALDH1A1 | |
| SCHEMBL6445765 | 0.69 | TDP1 (0.59) | TP53KMT2ANPSR1HSD17B10ALDH1A1 | |
| SCHEMBL13212285 | 0.69 | TP53 (0.79) | TP53KMT2ANPSR1HSD17B10ALDH1A1 | |
| SCHEMBL30434731 | 0.69 | CCR8 (0.67) | ALDH1A1HTTNAMPTCCR8KDM4E | |
| SCHEMBL7854832 | 0.69 | NPC1 (0.56) | TP53KMT2ANPSR1ALDH1A1L3MBTL1 | |
| SCHEMBL1161697 | 0.68 | MMP13 (0.82) | ALDH1A1HTTL3MBTL1HDAC1NAMPT | |
| SCHEMBL28277563 | 0.68 | KMT2A (0.64) | TP53KMT2ANPSR1HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020019414-A1 | N-aryl(thio)anthranilic acid amide derivatives, their preparation and their use as VEGF receptor tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2002-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019414-A1 | N-aryl(thio)anthranilic acid amide derivatives, their preparation and their use as VEGF receptor tyrosine kinase inhibitors | AXL, TYRO3, KDR | TP53 1416/4885KMT2A 2604/4885NPSR1 323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.