Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.50 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6283002 | 0.84 | CYP2D6 (0.65) | PLA2G10PLA2G5KMT2ASMN1; SMN2OPRM1 | |
| SCHEMBL28546761 | 0.83 | PLA2G10 (0.45) | PLA2G10PLA2G5KMT2ASMN1; SMN2OPRM1 | |
| SCHEMBL7366693 | 0.82 | TSHR (0.51) | KMT2ASMN1; SMN2POLBCYP2D6CYP2C9 | |
| SCHEMBL7199915 | 0.80 | PLA2G10 (0.63) | PLA2G10PLA2G5KMT2ASMN1; SMN2OPRM1 | |
| SCHEMBL7365707 | 0.79 | KMT2A (0.66) | KMT2ASMN1; SMN2POLBCYP2D6CYP2C9 | |
| SCHEMBL12957540 | 0.78 | KMT2A (0.54) | KMT2ASMN1; SMN2POLBCYP2D6CYP2C9 | |
| SCHEMBL7745615 | 0.78 | KMT2A (0.52) | KMT2ASMN1; SMN2POLBCYP2D6CYP2C9 | |
| SCHEMBL8293418 | 0.77 | OPRD1 (0.47) | KMT2AKDM4EL3MBTL1HDAC6MAPK1 | |
| SCHEMBL1488276 | 0.77 | L3MBTL1 (0.56) | KMT2APOLBCYP2D6CYP2C9CYP2C19 | |
| SCHEMBL1049753 | 0.76 | HDAC1 (0.50) | KMT2APOLBCYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819005-A4 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2001-03-21 | — | — | EP | disclosed |
| US-5773441-A | PRODRUGS; ANIMAL HUSBANDRY | ELI LILLY AND COMPANY (US) | 1998-06-30 | — | — | US | disclosed |
| EP-0819005-A1 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1998-01-21 | — | — | EP | disclosed |
| EP-0761220-A1 | 2-Acylaminopropanamides as growth hormone secretagogues | ELI LILLY AND COMPANY (US) | 1997-03-12 | — | — | EP | disclosed |
| US-5565568-A | USEFUL IN TREATMENT OR PREVENTION OF A PHYSIOLOGICAL DISORDER ASSOCIATED WITH AN EXCESS OF TACHYKININS | ELI LILLY AND COMPANY (US) | 1996-10-15 | — | — | US | disclosed |
| WO-1996031214-A1 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-10-10 | — | — | WO | disclosed |