Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.72 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | HPGD | P15428 | 6/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205521 | 0.80 | ALDH1A1 (0.67) | ALDH1A1KDM4EMAPTHPGDKMT2A | |
| SCHEMBL27774057 | 0.80 | KDM4E (0.60) | ALDH1A1KDM4EMAPTHPGDTDP1 | |
| SCHEMBL7740284 | 0.79 | JAK2 (0.49) | ALDH1A1KDM4EMAPTHPGDKMT2A | |
| SCHEMBL27795083 | 0.78 | PYGL (0.62) | ALDH1A1KDM4EMAPTHPGDTDP1 | |
| SCHEMBL27795086 | 0.78 | KDM4E (0.60) | ALDH1A1KDM4EMAPTHPGDTDP1 | |
| SCHEMBL19073035 | 0.76 | ALDH1A1 (0.73) | ALDH1A1KDM4EMAPTHPGDKMT2A | |
| SCHEMBL27743061 | 0.76 | FGFR1 (0.46) | ALDH1A1KDM4EMAPTHPGDTDP1 | |
| SCHEMBL3810147 | 0.74 | TRPV1 (0.66) | KDM4EPOLB | |
| SCHEMBL3813966 | 0.74 | TRPV1 (0.66) | KDM4EPOLB | |
| SCHEMBL3093023 | 0.73 | JAK2 (0.52) | ALDH1A1KDM4EMAPTTDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6413956-B1 | AGONISTS, ANTAGONISTS OR INVERSE AGONISTS AND LOCALIZATION PROBES FOR GAMMA AMINOBUTYRIC ACID BRAIN RECEPTORS; ANXIETY, DEPRESSION, DOWN SYNDROME, SLEEP AND SEIZURE DISORDERS, OVERDOSE WITH BENZODIAZEPINE DRUGS AND MEMORY ENHANCEMENT | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |