Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | JAK1 | P23458 | 2/20 | 0.49 |
| ▸ | TYK2 | P29597 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAP2 | P11137 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3093023 | 0.91 | JAK2 (0.52) | JAK2JAK1TYK2JAK3KDM4E | |
| SCHEMBL9051473 | 0.80 | HPGD (0.52) | JAK2HSD17B10JAK1TYK2JAK3 | |
| SCHEMBL7738734 | 0.79 | ALDH1A1 (0.72) | HSD17B10KDM4EHPGDKMT2AMAPT | |
| SCHEMBL15281971 | 0.79 | GAA (0.48) | JAK2HSD17B10KDM4EHPGDKMT2A | |
| SCHEMBL27743061 | 0.78 | FGFR1 (0.46) | HSD17B10KDM4EHPGDKMT2AMAPT | |
| SCHEMBL9596257 | 0.77 | HSD17B10 (0.59) | HSD17B10KDM4EHPGDKMT2AMAPT | |
| SCHEMBL6205521 | 0.77 | ALDH1A1 (0.67) | HSD17B10KDM4EHPGDKMT2AMAPT | |
| SCHEMBL4351617 | 0.74 | PRKDC (0.59) | JAK2HSD17B10JAK1TYK2JAK3 | |
| SCHEMBL30689022 | 0.73 | ALDH1A1 (0.62) | HSD17B10JAK1JAK3KDM4EHPGD | |
| SCHEMBL20935019 | 0.72 | HPGD (0.56) | HSD17B10KDM4EHPGDKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6413956-B1 | AGONISTS, ANTAGONISTS OR INVERSE AGONISTS AND LOCALIZATION PROBES FOR GAMMA AMINOBUTYRIC ACID BRAIN RECEPTORS; ANXIETY, DEPRESSION, DOWN SYNDROME, SLEEP AND SEIZURE DISORDERS, OVERDOSE WITH BENZODIAZEPINE DRUGS AND MEMORY ENHANCEMENT | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |