Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 20/20 | 0.45 |
| ▸ | NOS1 | P29475 | 20/20 | 0.45 |
| ▸ | NOS2 | P35228 | 20/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7740468 | 0.99 | NOS3 (0.46) | NOS3NOS1NOS2 | |
| SCHEMBL7734293 | 0.82 | NOS3 (0.50) | NOS3NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL7734155 | 0.81 | NOS3 (0.51) | NOS3NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL7738903 | 0.81 | NOS1 (0.37) | NOS3NOS1 | |
| Hydrochloric Acid SCHEMBL7742140 | 0.81 | NOS3 (0.44) | NOS3NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL7740440 | 0.80 | NOS3 (0.49) | NOS3NOS1NOS2 | |
| SCHEMBL7740427 | 0.80 | NOS1 (0.38) | NOS3NOS1NOS2 | |
| SCHEMBL7738898 | 0.76 | NOS3 (0.40) | NOS3NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL7738927 | 0.76 | NOS3 (0.41) | NOS3NOS1NOS2 | |
| SCHEMBL7739655 | 0.74 | KMT2A (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414005-B1 | BRAIN DISORDERS; ALZHEIMER'S DISEASE; PARKINSON'S DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-07-02 | — | — | US | claimed |
| EP-1043312-A1 | HETEROCYCLIC COMPOUNDS HAVING NOS INHIBITORY ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-10-11 | — | — | EP | claimed |
| US-6414005-B1 | BRAIN DISORDERS; ALZHEIMER'S DISEASE; PARKINSON'S DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-07-02 | — | — | US | disclosed |
| EP-1043312-A1 | HETEROCYCLIC COMPOUNDS HAVING NOS INHIBITORY ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-10-11 | — | — | EP | disclosed |