Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 7/20 | 0.36 |
| ▸ | MMP2 | P08253 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 4/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739776 | 1.00 | MMP9 (0.36) | MMP9MMP2ALDH1A1MMP12ACACB | |
| SCHEMBL7734657 | 0.86 | MMP2 (0.47) | MMP9MMP2MMP12 | |
| SCHEMBL7734661 | 0.86 | MMP2 (0.47) | MMP9MMP2MMP12 | |
| SCHEMBL7740873 | 0.75 | KDM4E (0.49) | MMP9MMP2ALDH1A1MMP12ANPEP | |
| SCHEMBL7740867 | 0.75 | KDM4E (0.49) | MMP9MMP2ALDH1A1MMP12ANPEP | |
| SCHEMBL7739817 | 0.74 | MMP2 (0.47) | MMP9MMP2ALDH1A1MMP12TAS1R3 | |
| SCHEMBL7739825 | 0.74 | MMP2 (0.47) | MMP9MMP2ALDH1A1MMP12TAS1R3 | |
| SCHEMBL7741002 | 0.72 | MMP2 (0.43) | MMP9MMP2MMP12 | |
| SCHEMBL7741004 | 0.72 | MMP2 (0.43) | MMP9MMP2MMP12 | |
| SCHEMBL7734969 | 0.72 | MMP2 (0.54) | MMP9MMP2MMP12MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | claimed |
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | disclosed |