Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 11/20 | 0.49 |
| ▸ | CTSL | P07711 | 11/20 | 0.49 |
| ▸ | CTSB | P07858 | 10/20 | 0.49 |
| ▸ | CTSK | P43235 | 9/20 | 0.49 |
| ▸ | CTSV | O60911 | 7/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739831 | 1.00 | CTSS (0.49) | CTSSCTSLCTSBCTSKCTSV | |
| SCHEMBL7741070 | 0.90 | PIN1 (0.39) | CTSSCTSLCTSBCTSKCTSV | |
| SCHEMBL7741076 | 0.90 | PIN1 (0.39) | CTSSCTSLCTSBCTSKCTSV | |
| SCHEMBL7740333 | 0.89 | CTSL (0.45) | CTSLPIN1HDAC1 | |
| SCHEMBL7740337 | 0.89 | CTSL (0.45) | CTSLPIN1HDAC1 | |
| SCHEMBL7741044 | 0.89 | MEN1 (0.46) | CTSLPIN1P2RY14HDAC1 | |
| SCHEMBL7741049 | 0.89 | MEN1 (0.46) | CTSLPIN1P2RY14HDAC1 | |
| SCHEMBL7740130 | 0.86 | HTT (0.44) | CTSLPIN1HTT | |
| SCHEMBL7740127 | 0.86 | HTT (0.44) | CTSLPIN1HTT | |
| SCHEMBL7742522 | 0.86 | HDAC1 (0.41) | CTSBHDAC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | disclosed |