Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739823 | 1.00 | ADRB2 (0.37) | ADRB2ADRB1ADRB3ALDH1A1SMN1; SMN2 | |
| SCHEMBL6300644 | 0.90 | MAPT (0.36) | ADRB2ADRB1ADRB3ALDH1A1SMN1; SMN2 | |
| SCHEMBL7740314 | 0.89 | ALDH1A1 (0.39) | ADRB2ADRB1ADRB3ALDH1A1SMN1; SMN2 | |
| SCHEMBL7740317 | 0.89 | ALDH1A1 (0.39) | ADRB2ADRB1ADRB3ALDH1A1SMN1; SMN2 | |
| SCHEMBL7740168 | 0.88 | CRHBP (0.43) | ALDH1A1SMN1; SMN2MAPTCRHBPCRHR2 | |
| SCHEMBL7740164 | 0.88 | CRHBP (0.43) | ALDH1A1SMN1; SMN2MAPTCRHBPCRHR2 | |
| SCHEMBL6300649 | 0.88 | ADRB2 (0.35) | ADRB2ADRB1ADRB3ALDH1A1SMN1; SMN2 | |
| SCHEMBL6300641 | 0.88 | ADRB2 (0.35) | ADRB2ADRB1ADRB3ALDH1A1SMN1; SMN2 | |
| SCHEMBL7742592 | 0.87 | NPC1 (0.36) | ALDH1A1 | |
| SCHEMBL7742596 | 0.87 | NPC1 (0.36) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | claimed |
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | disclosed |