Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7742329 | 0.86 | ALDH1A1 (0.52) | HPGDKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7734712 | 0.84 | ALDH1A1 (0.47) | HPGDKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7740373 | 0.83 | KMT2A (0.43) | KDM4EALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL31711485 | 0.77 | ALDH1A1 (0.56) | HPGDKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL25718794 | 0.77 | ALDH1A1 (0.56) | HPGDKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL23997191 | 0.77 | ALDH1A1 (0.56) | HPGDKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL23997320 | 0.76 | LMNA (0.69) | HPGDKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL30336888 | 0.76 | LMNA (0.69) | HPGDKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL23997318 | 0.74 | LMNA (0.58) | HPGDKDM4EALDH1A1SMN1; SMN2GRIN2D | |
| SCHEMBL30336892 | 0.74 | LMNA (0.58) | HPGDKDM4EALDH1A1SMN1; SMN2GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420410-B1 | ADMINISTERING N,N'-SUBSTITUTED BENZIMIDAZOL-2-ONES TO INDUCE APOPTOSIS IN NEOPLASTIC CELLS BUT NOT NORMAL CELLS; ANTICANCER, ANTITUMOR AGENT | CELL PATHWAYS, INC. | 2002-07-16 | — | — | US | disclosed |