Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7740710 | 0.85 | ALDH1A1 (0.45) | ALDH1A1KDM4ESMN1; SMN2LMNAMEN1 | |
| SCHEMBL7740310 | 0.84 | HPGD (0.55) | ALDH1A1KDM4EHPGDSMN1; SMN2PKM | |
| SCHEMBL23997319 | 0.79 | LMNA (0.60) | ALDH1A1KDM4ELMNATSHRMEN1 | |
| SCHEMBL7742329 | 0.79 | ALDH1A1 (0.52) | ALDH1A1KDM4EHPGDSMN1; SMN2P2RX7 | |
| SCHEMBL30345078 | 0.79 | LMNA (0.60) | ALDH1A1KDM4ELMNATSHRMEN1 | |
| SCHEMBL7740373 | 0.73 | KMT2A (0.43) | ALDH1A1KDM4ESMN1; SMN2LMNAMEN1 | |
| SCHEMBL7742335 | 0.72 | MAPT (0.52) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL2311046 | 0.71 | DAO (0.50) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL13332558 | 0.70 | CYP1A2 (0.62) | ALDH1A1KDM4EHPGDSMN1; SMN2ADORA3 | |
| SCHEMBL31711485 | 0.70 | ALDH1A1 (0.56) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420410-B1 | ADMINISTERING N,N'-SUBSTITUTED BENZIMIDAZOL-2-ONES TO INDUCE APOPTOSIS IN NEOPLASTIC CELLS BUT NOT NORMAL CELLS; ANTICANCER, ANTITUMOR AGENT | CELL PATHWAYS, INC. | 2002-07-16 | — | — | US | disclosed |