SCHEMBL7740372

SCHEMBL7740372

[CH2]c1ccc2[nH]nc(CCCC)c2c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.37
HSP90AB1 P08238 1/20 0.37
HCAR3 P49019 2/20 0.33
HCAR2 Q8TDS4 2/20 0.33
HTT P42858 2/20 0.33
MAPT P10636 1/20 0.33
GABRP O00591 1/20 0.33
GABRD O14764 1/20 0.33
GABRA1 P14867 1/20 0.33
IDO1 P14902 1/20 0.33
GABRB1 P18505 1/20 0.33
GABRG2 P18507 1/20 0.33
GABRB3 P28472 1/20 0.33
GABRA5 P31644 1/20 0.33
GABRA3 P34903 1/20 0.33
GABRA2 P47869 1/20 0.33
GABRB2 P47870 1/20 0.33
GABRA4 P48169 1/20 0.33
GABRE P78334 1/20 0.33
GABRA6 Q16445 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7352623 0.83 TTK (0.35) MAPK1TTKJAK2GSK3BROCK2
SCHEMBL7740374 0.83 MAPT (0.50) HTTMAPTMAPK1ALDH1A1MAP2K4
SCHEMBL15826217 0.78 HTR1A (0.48) MAPTALDH1A1HTR1ATP53LMNA
SCHEMBL22632566 0.77 PDPK1 (0.50) JAK2HTR1AGSK3BMAP4K4CDK2
SCHEMBL7134511 0.77 CYP3A4 (0.44) HSP90AA1HSP90AB1HCAR3HCAR2HTT
SCHEMBL1326632 0.77 KDM4E (0.46) HTTGABRPGABRDGABRA1IDO1
SCHEMBL24025971 0.75 HTR1A (0.38) HSP90AA1HSP90AB1HCAR3HCAR2MAPT
SCHEMBL22643956 0.75 HTR1D (0.40) HSP90AA1HSP90AB1HCAR3HCAR2HTT
SCHEMBL18691011 0.75 ALDH1A1 (0.51) HSP90AA1HSP90AB1HCAR3HCAR2MAPT
SCHEMBL7356527 0.74 ADORA2A (0.46) MAPK1JAK2CYP1A2MAP2K4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE37781-E1 VIRICIDES, PROTEASE INHIBITOR DUPONT PHARMACEUTICALS COMPANY 2002-07-02 US claimed
US-5610294-A VIRAL TREATMENT THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1997-03-11 US claimed