Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | HTR1D | P28221 | 3/20 | 0.38 |
| ▸ | HTR1B | P28222 | 3/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.38 |
| ▸ | HTR3B | O95264 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR1E | P28566 | 2/20 | 0.38 |
| ▸ | HTR1F | P30939 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | HTR3A | P46098 | 2/20 | 0.38 |
| ▸ | HTR5A | P47898 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15826217 | 0.81 | HTR1A (0.48) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL7134511 | 0.79 | CYP3A4 (0.44) | HTR1AHTR1DHTR2AHTR2CHTR2B | |
| SCHEMBL22632566 | 0.79 | PDPK1 (0.50) | HTR1AHTR2AHTR2CHTR7HTR2B | |
| SCHEMBL22643956 | 0.77 | HTR1D (0.40) | HTR1DHTR1BMAPTKDM4EGAA | |
| SCHEMBL14863730 | 0.76 | MEN1 (0.47) | HTR1ATSHRHSD17B10 | |
| SCHEMBL7740374 | 0.76 | MAPT (0.50) | MAPTKDM4EALDH1A1GAATSHR | |
| SCHEMBL2876088 | 0.75 | MEN1 (0.45) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL22643896 | 0.75 | GAA (0.34) | ALDH1A1GAAHPGDHSD17B10GSK3B | |
| SCHEMBL21217945 | 0.75 | TSHR (0.49) | HTR1AHTR1DHTR1BHTR3EHTR3B | |
| SCHEMBL7740372 | 0.75 | HSP90AA1 (0.37) | HTR1AMAPTALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210355112-A1 | MODULATORS OF THR-BETA AND METHODS OF USE THEREOF | ALIGOS THERAPEUTICS, INC. (US) | 2021-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210355112-A1 | MODULATORS OF THR-BETA AND METHODS OF USE THEREOF | THRB, THRA, TRHR | HTR1A 1685/4885HTR1D 1537/4885HTR1B 597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.