Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6680614 | 0.84 | ALDH1A1 (0.52) | NPSR1MAPTHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL7742120 | 0.84 | ALDH1A1 (0.44) | NPSR1ITGA4ITGB7MAPTHTT | |
| SCHEMBL6675790 | 0.83 | ALDH1A1 (0.54) | NPSR1MAPTHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL6677398 | 0.83 | ITGA4 (0.43) | TDP1ITGA4ITGB7MAPTHTT | |
| SCHEMBL6681036 | 0.83 | ALDH1A1 (0.45) | NPSR1TDP1ITGA4ITGB7MAPT | |
| SCHEMBL6676629 | 0.82 | ALDH1A1 (0.45) | ITGA4ITGB7MAPTHTTALOX5 | |
| SCHEMBL6674892 | 0.82 | MEN1 (0.44) | NPSR1ITGA4ITGB7MAPTALOX5 | |
| SCHEMBL27495191 | 0.82 | TDP1 (0.48) | NPSR1TDP1MAPTHTTALDH1A1 | |
| SCHEMBL6681796 | 0.81 | ALDH1A1 (0.49) | ITGA4ITGB7MAPTHTTALOX5 | |
| SCHEMBL6676364 | 0.81 | TP53 (0.43) | ITGA4ITGB7MAPTHTTALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414005-B1 | BRAIN DISORDERS; ALZHEIMER'S DISEASE; PARKINSON'S DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-07-02 | — | — | US | disclosed |
| EP-1043312-A1 | HETEROCYCLIC COMPOUNDS HAVING NOS INHIBITORY ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-10-11 | — | — | EP | disclosed |