Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7745371 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL27563812 | 0.80 | LMNA (0.48) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL9627031 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL6659330 | 0.76 | ESR2 (0.43) | SMN1; SMN2LMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL9457164 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL6661592 | 0.75 | MEN1 (0.52) | SMN1; SMN2HRH2HRH1ALDH1A1HPGD | |
| SCHEMBL574934 | 0.75 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| Iodide SCHEMBL7860350 | 0.74 | MEN1 (0.51) | SMN1; SMN2HRH2HRH1ALDH1A1HPGD | |
| SCHEMBL30643716 | 0.74 | HRH2 (0.47) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL29736653 | 0.73 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAPOLBHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080075-A4 | PIPERIDIDINYL AND N-AMIDINOPIPERIDINYL DERIVATIVES | AVENTIS PHARM PROD INC (US) | 2001-06-27 | — | — | EP | disclosed |
| EP-1080075-A1 | PIPERIDIDINYL AND N-AMIDINOPIPERIDINYL DERIVATIVES | Aventis Pharmaceuticals Products Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999048870-A1 | PIPERIDIDINYL AND N-AMIDINOPIPERIDINYL DERIVATIVES | AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) | 1999-09-30 | — | — | WO | disclosed |