Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HRH2 | P25021 | 6/20 | 0.41 |
| ▸ | HRH1 | P35367 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9625460 | 0.92 | SMN1; SMN2 (0.39) | SMN1; SMN2LMNAPOLBALDH1A1KDM4E | |
| SCHEMBL9624898 | 0.87 | MAPT (0.44) | SMN1; SMN2LMNAPOLBALDH1A1KDM4E | |
| SCHEMBL9457164 | 0.86 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL9626334 | 0.83 | POLB (0.34) | SMN1; SMN2LMNAPOLBALDH1A1KDM4E | |
| SCHEMBL9625616 | 0.82 | SMN1; SMN2 (0.33) | SMN1; SMN2LMNAPOLBALDH1A1MEN1 | |
| SCHEMBL27563812 | 0.80 | LMNA (0.48) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL7740552 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL9625448 | 0.78 | L3MBTL1 (0.40) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL9626076 | 0.78 | OPRM1 (0.47) | SMN1; SMN2POLBHRH2HRH1ALDH1A1 | |
| SCHEMBL9625561 | 0.78 | ERN1 (0.43) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308283-B1 | 1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXALDEHYDE OXIME DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1992-01-22 | — | — | EP | disclosed |
| EP-0308283-A1 | 1,2,5,6-Tetrahydropyridine-3-carboxaldehyde oxime derivatives, process for their preparation, their use as pharmaceutical compounds and compositions containing them | ROUSSEL-UCLAF (FR) | 1989-03-22 | — | — | EP | disclosed |