Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 7/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 7/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739851 | 0.91 | PRKAG1 (0.38) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL7740615 | 0.91 | PRKAG1 (0.36) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL7741122 | 0.88 | PRKAG1 (0.38) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL7739647 | 0.87 | PRKAG1 (0.38) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL7739968 | 0.85 | GRIN2D (0.34) | PRKAG1PRKAA1PRKAB1MEN1MAPT | |
| SCHEMBL7741121 | 0.84 | IDH1 (0.36) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL7740618 | 0.84 | PTGES (0.38) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL7741420 | 0.84 | CHRNA7 (0.36) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL7742775 | 0.84 | CYP1A2 (0.40) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL7742690 | 0.83 | PTGES (0.35) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420386-B1 | SPINAL TRAUMATISM, EPILEPSY, CHRONIC NEURODEGENERATIVE DISEASES SUCH AS ALZHEIMER'S DISEASE, SCHIZOPHRENIA, LATERAL AMYOTROPHIC SCLEROSIS OR HUNTINGTON'S CHOREA. | LES LABORATORIES SERVIER (FR) | 2002-07-16 | — | — | US | disclosed |