Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7735087 | 0.82 | NTRK1 (0.35) | NTRK1S1PR1ADORA3ADORA2AADORA1 | |
| SCHEMBL7735090 | 0.81 | NTRK1 (0.36) | NTRK1S1PR1KDM4E | |
| SCHEMBL7742754 | 0.81 | PRKAG1 (0.42) | GRIK1GPR84 | |
| SCHEMBL6940851 | 0.76 | TNKS (0.39) | CYP1A2CYP2C9 | |
| SCHEMBL7739865 | 0.76 | GRIA1 (0.61) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7741274 | 0.75 | GRIK1 (0.50) | KDM4EPOLBGRIK1GRIN2DGRIN3B | |
| SCHEMBL6927437 | 0.74 | CA1 (0.41) | KDM4EALDH1A1CYP2C9GRIA1GRIA2 | |
| SCHEMBL28748171 | 0.73 | GRIA1 (0.32) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6937214 | 0.73 | ADORA3 (0.38) | NTRK1S1PR1ADORA3ADORA2AADORA1 | |
| SCHEMBL7740551 | 0.72 | PRKAG1 (0.43) | POLBKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420386-B1 | SPINAL TRAUMATISM, EPILEPSY, CHRONIC NEURODEGENERATIVE DISEASES SUCH AS ALZHEIMER'S DISEASE, SCHIZOPHRENIA, LATERAL AMYOTROPHIC SCLEROSIS OR HUNTINGTON'S CHOREA. | LES LABORATORIES SERVIER (FR) | 2002-07-16 | — | — | US | disclosed |