Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 6/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.42 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.42 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.42 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | HPN | P05981 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | FASN | P49327 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7741244 | 0.88 | PTGES (0.40) | PRKAG1PRKAB1PRKAA1FASN | |
| SCHEMBL6935464 | 0.87 | PRKAG1 (0.43) | PRKAG1PRKAB1PRKAA2PRKAA1PRKAB2 | |
| SCHEMBL7740551 | 0.87 | PRKAG1 (0.43) | PRKAG1PRKAB1PRKAA1FASN | |
| SCHEMBL6940851 | 0.84 | TNKS (0.39) | PRKAG1PRKAB1PRKAA2PRKAA1PRKAB2 | |
| SCHEMBL28747976 | 0.84 | PRKAG1 (0.37) | PRKAG1PRKAB1PRKAA2PRKAA1PRKAB2 | |
| SCHEMBL7739877 | 0.84 | RHEB (0.43) | PRKAG1PRKAB1PRKAA1FASN | |
| SCHEMBL7734991 | 0.84 | GRIN2D (0.44) | — | |
| SCHEMBL7741098 | 0.83 | PTGS2 (0.38) | PRKAG1PRKAB1PRKAA1 | |
| SCHEMBL7741263 | 0.83 | GRIA1 (0.41) | — | |
| SCHEMBL7742964 | 0.83 | GRIN2D (0.40) | PRKAG1PRKAB1PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420386-B1 | SPINAL TRAUMATISM, EPILEPSY, CHRONIC NEURODEGENERATIVE DISEASES SUCH AS ALZHEIMER'S DISEASE, SCHIZOPHRENIA, LATERAL AMYOTROPHIC SCLEROSIS OR HUNTINGTON'S CHOREA. | LES LABORATORIES SERVIER (FR) | 2002-07-16 | — | — | US | disclosed |
| JP-2001278890-A | ARYL OR HETEROARYLQUNOLINYLPHOSPHONIC ACID COMPOUND, METHOD FOR PRODUCING THE SAME AND MEDICINAL COMPOSITION CONTAINING THE SAME | ADIR | 2001-10-10 | — | — | JP | disclosed |