Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 9/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27521768 | 0.78 | PDPK1 (0.36) | PDPK1DRD2MTNR1AKDM4E | |
| SCHEMBL7743295 | 0.78 | HTR1A (0.63) | HTR1ANR1I2PDPK1DRD2DRD4 | |
| SCHEMBL7741698 | 0.77 | HTR1A (0.65) | HTR1AADRA1AMTNR1AMTNR1B | |
| SCHEMBL7740248 | 0.75 | HTR1A (0.56) | HTR1AADRA1AMTNR1AMTNR1B | |
| SCHEMBL6678870 | 0.74 | MTNR1A (0.57) | NR1I2PDPK1DRD2DRD4DRD3 | |
| SCHEMBL7735727 | 0.73 | MTNR1A (0.65) | HTR1AMTNR1AMTNR1B | |
| SCHEMBL7743369 | 0.73 | NR1I2 (0.40) | NR1I2PDPK1DRD2DRD4DRD3 | |
| SCHEMBL14322492 | 0.72 | DRD2 (0.55) | HTR1APDPK1DRD2DRD4DRD3 | |
| SCHEMBL6633828 | 0.68 | MTNR1A (0.58) | MTNR1AMTNR1B | |
| SCHEMBL28458042 | 0.63 | CA1 (0.48) | DRD2DRD4DRD3ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423870-B1 | ANTICOAGULANTS; CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS | LES LABORATOIRES SERVIER (FR) | 2002-07-23 | — | — | US | disclosed |