Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HMGCR | P04035 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 6/20 | 0.37 |
| ▸ | ACLY | P53396 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL15779277 | 0.95 | ALDH1A1 (0.79) | ALDH1A1LMNATSHRMEN1KMT2A | |
| Citric Acid SCHEMBL73266 | 0.95 | ALDH1A1 (0.79) | ALDH1A1LMNATSHRMEN1KMT2A | |
| Citric Acid SCHEMBL332489 | 0.95 | ALDH1A1 (0.79) | ALDH1A1LMNATSHRMEN1KMT2A | |
| Citric Acid SCHEMBL27647752 | 0.95 | ALDH1A1 (0.79) | ALDH1A1LMNATSHRMEN1KMT2A | |
| Citric Acid SCHEMBL10520117 | 0.95 | ALDH1A1 (0.79) | ALDH1A1LMNATSHRMEN1KMT2A | |
| Citric Acid SCHEMBL23012587 | 0.93 | ALDH1A1 (0.75) | ALDH1A1LMNATSHRMEN1KMT2A | |
| Citric Acid SCHEMBL15653350 | 0.93 | ALDH1A1 (0.75) | ALDH1A1LMNATSHRMEN1KMT2A | |
| Citric Acid SCHEMBL9333028 | 0.93 | ALDH1A1 (0.75) | ALDH1A1LMNATSHRMEN1KMT2A | |
| Citric Acid SCHEMBL11531681 | 0.93 | ALDH1A1 (0.75) | ALDH1A1LMNATSHRMEN1KMT2A | |
| Citric Acid SCHEMBL6131060 | 0.93 | ALDH1A1 (0.75) | ALDH1A1LMNATSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210115430-A1 | Immobilized Enzyme Complexes and Related Methods | THE CURATORS OF THE UNIVERSITY OF MISSOURI | 2021-04-22 | — | — | US | disclosed |
| EP-3625335-A1 | IMMOBILIZED ENZYME COMPLEXES AND RELATED METHODS | The Curators of the University of Missouri (US) | 2020-03-25 | — | — | EP | disclosed |
| WO-2018213482-A9 | IMMOBILIZED ENZYME COMPLEXES AND RELATED METHODS | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2020-03-05 | — | — | WO | disclosed |
| WO-2018213482-A1 | IMMOBILIZED ENZYME COMPLEXES AND RELATED METHODS | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2018-11-22 | — | — | WO | disclosed |
| US-20010006772-A1 | Method for conversion of blood type | GOLDSTEIN JACK (US) | 2001-07-05 | — | — | US | disclosed |
| EP-0951216-A4 | METHOD FOR CONVERSION OF BLOOD TYPE | NEW YORK BLOOD CT INC (US) | 2001-05-30 | — | — | EP | disclosed |
| EP-0951216-A1 | METHOD FOR CONVERSION OF BLOOD TYPE | THE NEW YORK BLOOD CENTER (US) | 1999-10-27 | — | — | EP | disclosed |
| EP-0807165-A4 | RECOMBINANT -g(a)-GALACTOSIDASE ENZYME | NEW YORK BLOOD CENTER INC (US) | 1998-07-15 | — | — | EP | disclosed |
| WO-1998021944-A1 | METHOD FOR CONVERSION OF BLOOD TYPE | NEW YORK BLOOD CENTER (US) | 1998-05-28 | — | — | WO | disclosed |
| EP-0807165-A1 | RECOMBINANT $g(a)-GALACTOSIDASE ENZYME | THE NEW YORK BLOOD CENTER, INC. (US) | 1997-11-19 | — | — | EP | disclosed |
| EP-0721339-A4 | RECOMBINANT -g(a)-GALACTOSIDASE ENZYME AND cDNA ENCODING SAID ENZYME | NEW YORK BLOOD CENTER INC (US) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996023869-A1 | RECOMBINANT α-GALACTOSIDASE ENZYME | NEW YORK BLOOD CENTER, INC. (US) | 1996-08-08 | — | — | WO | disclosed |
| EP-0721339-A1 | RECOMBINANT $g(a)-GALACTOSIDASE ENZYME AND cDNA ENCODING SAID ENZYME | New York Blood Center, Inc. (US) | 1996-07-17 | — | — | EP | disclosed |
| WO-1995007088-A1 | RECOMBINANT α-GALACTOSIDASE ENZYME AND cDNA ENCODING SAID ENZYME | NEW YORK BLOOD CENTER, INC. (US) | 1995-03-16 | — | — | WO | disclosed |