Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7737452 | 0.81 | APLNR (0.43) | APLNRHSP90AA1L3MBTL1NPC1SLC40A1 | |
| SCHEMBL12456472 | 0.77 | APLNR (0.42) | APLNRHSP90AA1L3MBTL1NPC1LRRK2 | |
| SCHEMBL8117319 | 0.77 | L3MBTL1 (0.49) | APLNRHSP90AA1L3MBTL1NPC1SLC40A1 | |
| SCHEMBL27002527 | 0.76 | L3MBTL1 (0.46) | HSP90AA1L3MBTL1NPC1LRRK2SLC40A1 | |
| SCHEMBL7743445 | 0.76 | HSP90AA1 (0.46) | HSP90AA1L3MBTL1NPC1LRRK2SLC40A1 | |
| SCHEMBL8112804 | 0.73 | DRD1 (0.33) | APLNRLRRK2DRD1 | |
| SCHEMBL8584090 | 0.71 | APLNR (0.31) | APLNR | |
| SCHEMBL6582228 | 0.71 | — | — | |
| SCHEMBL14257751 | 0.71 | APLNR (0.47) | APLNRHSP90AA1L3MBTL1NPC1CCR1 | |
| SCHEMBL7743453 | 0.71 | APLNR (0.47) | APLNRHSP90AA1L3MBTL1NPC1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423724-B1 | PREVENTION, THERAPY DISEASE | THE PROCTER & GAMBLE COMPANY | 2002-07-23 | — | — | US | disclosed |
| EP-0734261-B1 | 7-(2-IMIDAZOLINYLAMINO)QUINOLINE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | PROCTER & GAMBLE (US) | 2001-06-27 | — | — | EP | disclosed |
| US-5916900-A | TREATMENT OF NASAL CONGESTION, ASTHMA, COUGH, CARDIOVASCULAR DISORDERS, OCULAR DISORDERS, GASTROINTESTINAL DISORDERS, MIGRAINES, SUSBSTANCE ABUSE | THE PROCTER & GAMBLE COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| US-5716966-A | RESPIRATORY SYSTEM DISORDERS; VISION DEFECTS; GASTROINTESTINAL DISORDERS | THE PROCTER & GAMBLE COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| US-5576437-A | 7-(2-imidazolnylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists | THE PROCTER & GAMBLE COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| EP-0734261-A1 | 7-(2-IMIDAZOLINYLAMINO)QUINOLINE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995020386-A1 | 7-(2-IMIDAZOLINYLAMINO)QUINOLINE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1995-08-03 | — | — | WO | disclosed |