Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 2/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CCR8 | P51685 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27002527 | 0.81 | L3MBTL1 (0.46) | HSP90AA1NPC1L3MBTL1HSP90AB1LRRK2 | |
| SCHEMBL11973624 | 0.77 | MEN1 (0.54) | HSP90AA1NPC1L3MBTL1HSP90AB1IDO1 | |
| SCHEMBL3194949 | 0.77 | HSP90AA1 (0.56) | HSP90AA1NPC1L3MBTL1HSP90AB1IDO1 | |
| SCHEMBL24713060 | 0.76 | KDM4E (0.42) | NSD2MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL9029872 | 0.76 | PRMT5 (0.45) | HSP90AA1NPC1L3MBTL1HSP90AB1IDO1 | |
| SCHEMBL7742986 | 0.76 | APLNR (0.41) | HSP90AA1NPC1L3MBTL1LRRK2SLC40A1 | |
| SCHEMBL7743581 | 0.76 | L3MBTL1 (0.50) | HSP90AA1NPC1L3MBTL1HSP90AB1IDO1 | |
| SCHEMBL3525315 | 0.73 | MEN1 (0.49) | HSP90AA1NPC1L3MBTL1LRRK2NSD2 | |
| SCHEMBL11908005 | 0.73 | CCR1 (0.56) | HSP90AA1NPC1L3MBTL1LRRK2SLC40A1 | |
| SCHEMBL15703114 | 0.73 | CCR1 (0.41) | HSP90AA1NPC1L3MBTL1LRRK2SLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423724-B1 | PREVENTION, THERAPY DISEASE | THE PROCTER & GAMBLE COMPANY | 2002-07-23 | — | — | US | disclosed |
| CN-1085945-C | 7-(2-imidazolinylamino) quinoline compounds as alpha-2 adrenoceptor agonists | PROCTER & GAMBLE (US) | 2002-06-05 | — | — | CN | disclosed |
| EP-0734261-B1 | 7-(2-IMIDAZOLINYLAMINO)QUINOLINE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | PROCTER & GAMBLE (US) | 2001-06-27 | — | — | EP | disclosed |
| US-5916900-A | TREATMENT OF NASAL CONGESTION, ASTHMA, COUGH, CARDIOVASCULAR DISORDERS, OCULAR DISORDERS, GASTROINTESTINAL DISORDERS, MIGRAINES, SUSBSTANCE ABUSE | THE PROCTER & GAMBLE COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| US-5716966-A | RESPIRATORY SYSTEM DISORDERS; VISION DEFECTS; GASTROINTESTINAL DISORDERS | THE PROCTER & GAMBLE COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| CN-1137754-A | 7-(2-imidazolinylamino) quinoline compounds as alpha-2 adrenoceptor agonists | PROCTER & GAMBLE (US) | 1996-12-11 | — | — | CN | disclosed |
| US-5576437-A | 7-(2-imidazolnylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists | THE PROCTER & GAMBLE COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| EP-0734261-A1 | 7-(2-IMIDAZOLINYLAMINO)QUINOLINE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995020386-A1 | 7-(2-IMIDAZOLINYLAMINO)QUINOLINE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1995-08-03 | — | — | WO | disclosed |