Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7743099 | 1.00 | NPC1 (0.56) | NPC1RAB9AHDAC3HDAC1HDAC7 | |
| SCHEMBL27725901 | 0.82 | NPC1 (0.54) | NPC1RAB9AHDAC3HDAC1HDAC7 | |
| SCHEMBL5318792 | 0.79 | NPC1 (0.59) | NPC1RAB9AHDAC3HDAC1HDAC7 | |
| SCHEMBL1723352 | 0.77 | NPC1 (0.65) | NPC1RAB9AHDAC3HDAC1HDAC7 | |
| SCHEMBL2434556 | 0.74 | LMNA (0.55) | NPC1RAB9AALDH1A1KMT2AGAA | |
| SCHEMBL5385289 | 0.74 | NPC1 (0.61) | NPC1RAB9AHDAC3HDAC1HDAC7 | |
| SCHEMBL15869135 | 0.74 | LMNA (0.55) | NPC1RAB9AALDH1A1KMT2AGAA | |
| SCHEMBL28401199 | 0.74 | NPC1 (0.61) | NPC1RAB9AHDAC3HDAC1HDAC7 | |
| SCHEMBL28877332 | 0.74 | HDAC3 (0.62) | NPC1RAB9AHDAC3HDAC1HDAC6 | |
| SCHEMBL15450091 | 0.74 | LMNA (0.55) | NPC1RAB9AALDH1A1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002532414-A | — | — | 2002-10-02 | — | — | JP | claimed |
| EP-1140046-A1 | USE OF A MEK INHIBITOR FOR PREVENTING TRANSPLANT REJECTION | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | claimed |
| WO-2000035435-A1 | USE OF A MEK INHIBITOR FOR PREVENTING TRANSPLANT REJECTION | WARNER-LAMBERT COMPANY (US) | 2000-06-22 | — | — | WO | claimed |