Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16875729 | 0.88 | ALDH1A1 (0.45) | NPC1RAB9AALDH1A1POLBMAPT | |
| SCHEMBL28576226 | 0.83 | NPC1 (0.56) | NPC1RAB9AALDH1A1POLBMAPT | |
| SCHEMBL11113240 | 0.83 | HDAC1 (0.50) | NPC1RAB9AALDH1A1POLBMAPT | |
| SCHEMBL8382795 | 0.81 | GAA (0.53) | NPC1RAB9AALDH1A1KMT2ALMNA | |
| SCHEMBL12374695 | 0.81 | RAB9A (0.42) | NPC1RAB9AALDH1A1POLBKMT2A | |
| SCHEMBL11697933 | 0.80 | PKM (0.63) | NPC1RAB9AALDH1A1POLBMAPT | |
| SCHEMBL2282647 | 0.80 | UNG (0.49) | NPC1RAB9AALDH1A1HDAC3HDAC1 | |
| SCHEMBL7743095 | 0.79 | NPC1 (0.56) | NPC1RAB9AALDH1A1POLBMAPT | |
| SCHEMBL7743099 | 0.79 | NPC1 (0.56) | NPC1RAB9AALDH1A1POLBMAPT | |
| SCHEMBL9402706 | 0.79 | ALDH1A1 (0.44) | NPC1RAB9AALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841740-A1 | 3,4,(5)-SUBSTITUTED TETRAHVDROPYRIDINES | Novartis AG (CH) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006074924-A1 | 3,4,(5)-SUBSTITUTED TETRAHVDROPYRIDINES | NOVARTIS AG (CH) | 2006-07-20 | — | — | WO | disclosed |
| US-5223384-A | Multilayer; paper support, subbing and photosensitive layer | KONICA CORPORATION (JP) | 1993-06-29 | — | — | US | disclosed |
| EP-0103895-A2 | Novel hydroxylamine derivatives, production and use thereof | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1984-03-28 | — | — | EP | disclosed |
| US-4008192-A | Polyisocyanates blocked with hydroxamic acid esters or acyl hydroxamates | AKZO N.V. (NL) | 1977-02-15 | — | — | US | disclosed |