SCHEMBL7743273

SCHEMBL7743273

CC1=C(c2ccccc2)c2cc3c(cc2C1[Si](C)(C)NC1CCCCC1)CCC3

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.34
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
NPC1 O15118 3/20 0.34
NR2F2 P24468 1/20 0.34
ADORA2A P29274 1/20 0.32
ADORA1 P30542 1/20 0.32
S1PR1 P21453 1/20 0.32
KDM4E B2RXH2 4/20 0.32
LMNA P02545 3/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
MAPT P10636 2/20 0.32
ATM Q13315 1/20 0.31
ALDH1A1 P00352 3/20 0.31
NPSR1 Q6W5P4 2/20 0.30
HTT P42858 2/20 0.30
TP53 P04637 1/20 0.30
HPGD P15428 1/20 0.30
TSHR P16473 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7737208 0.82 MEN1 (0.32) MEN1KMT2ALMNAHPGD
SCHEMBL7741876 0.70 MEN1 (0.32) MEN1KMT2ALMNAHPGD
SCHEMBL7193086 0.66 MEN1 (0.36) RAB9AMEN1KMT2ANPC1NR2F2
SCHEMBL7949383 0.62
SCHEMBL7742391 0.61 TAS1R3 (0.38) MEN1KMT2AKDM4EMAPTALDH1A1
SCHEMBL8024127 0.60 TAS1R3 (0.37) MEN1KMT2AKDM4EMAPTALDH1A1
SCHEMBL7745069 0.60 CDC25B (0.32)
SCHEMBL6151121 0.60
SCHEMBL8073695 0.59
SCHEMBL11381460 0.58 EPHX2 (0.42) RAB9AKDM4ELMNASMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6420507-B1 COORDINATION CATALYSTS FOR POLYMERS THE DOW CHEMICAL COMPANY 2002-07-16 US disclosed
EP-0946575-B1 FUSED RING SUBSTITUTED INDENYL METAL COMPLEXES AND POLYMERIZATION PROCESS DOW CHEMICAL CO (US) 2001-10-10 EP disclosed
US-6034022-A COORDINATION POLYMERIZATION CATALYST THE DOW CHEMICAL COMPANY (US) 2000-03-07 US disclosed
EP-0977787-A1 OLEFIN POLYMERS PREPARED WITH SUBSTITUTED INDENYL CONTAINING METAL COMPLEXES THE DOW CHEMICAL COMPANY (US) 2000-02-09 EP disclosed
US-5965756-A COORDINATION CATALYSTS AS ADDITION POLYMERIZATION CATALYSTS THE DOW CHEMICAL COMPANY (US) 1999-10-12 US disclosed
EP-0946575-A1 FUSED RING SUBSTITUTED INDENYL METAL COMPLEXES AND POLYMERIZATION PROCESS THE DOW CHEMICAL COMPANY (US) 1999-10-06 EP disclosed
WO-1998049211-A1 OLEFIN POLYMERS PREPARED WITH SUBSTITUTED INDENYL CONTAINING METAL COMPLEXES THE DOW CHEMICAL COMPANY (US) 1998-11-05 WO disclosed
WO-1998027103-A1 FUSED RING SUBSTITUTED INDENYL METAL COMPLEXES AND POLYMERIZATION PROCESS THE DOW CHEMICAL COMPANY (US) 1998-06-25 WO disclosed